{"id":"W3017316429","doi":"10.1007/s12325-020-01327-9","title":"Polyvalent Human Immune Globulin: A Prospective, Open-Label Study Assessing Anti-Hepatitis A Virus (HAV) Antibody Levels, Pharmacokinetics, and Safety in HAV-Seronegative Healthy Subjects","year":2020,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Hepatitis Viruses Studies and Epidemiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"Grifols","keywords":"Medicine; Cmax; Adverse effect; Tolerability; Pharmacokinetics; Internal medicine; Titer; Antibody; Antibody titer; Hepatitis A; Gastroenterology; Hepatitis; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002795393,0.001512595,0.001501615,0.0004222534,0.0004818013,0.0007640594,0.0005724735,0.001264058,0.001343558],"category_scores_gemma":[0.001447132,0.0006917709,0.0007395947,0.0003435601,0.00161527,0.001021374,0.0003754332,0.001716256,0.0004626448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236141,"about_ca_system_score_gemma":0.0007608432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000473774,"about_ca_topic_score_gemma":0.0005725056,"domain_scores_codex":[0.9991508,0.0004476162,0.00005240717,0.0001567655,0.00009732095,0.00009518372],"domain_scores_gemma":[0.9984587,0.0004275526,0.0003208129,0.0001778089,0.0001075294,0.0005076237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7155429,0.1284462,0.0493179,0.0005025686,0.0009759863,0.000310265,0.0005344984,0.001073693,0.05648888,0.0001146345,0.0004883218,0.04620408],"study_design_scores_gemma":[0.07564181,0.8880922,0.03258448,0.00001247507,0.0002192631,0.0001176214,0.00006029763,0.0006889789,0.002133067,0.00005467517,0.0003738212,0.00002145055],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998725,0.000303294,0.0002714694,0.00002929731,0.00001603995,0.0003876582,0.00008823312,0.00001881898,0.000160104],"genre_scores_gemma":[0.9973368,0.0003244779,0.000758907,0.0001968325,0.00007635542,0.0005193104,0.0002317383,0.000007438693,0.0005482506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002795393,"threshold_uncertainty_score":0.01478368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1037419170589214,"score_gpt":0.4508958617937832,"score_spread":0.3471539447348617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}