{"id":"W3017396019","doi":"10.1016/j.yjmcc.2020.04.004","title":"The amino terminal domain plays an important role in transjunctional voltage-dependent gating kinetics of Cx45 gap junctions","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Gating; Gap junction; Connexin; Conductance; Biophysics; Coupling (piping); Chemistry; Intracellular; Biology; Physics; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003562426,0.000242225,0.0003150828,0.00009735983,0.000397041,0.0005248727,0.0003000612,0.0004590593,0.003463881],"category_scores_gemma":[0.001030275,0.0001725656,0.0002173321,0.00009598225,0.0003291784,0.001078881,0.0002165114,0.0007540772,0.0007741282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002899623,"about_ca_system_score_gemma":0.0002597128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005405137,"about_ca_topic_score_gemma":0.0005346207,"domain_scores_codex":[0.9998705,0.00002265178,0.00001281385,0.00003370467,0.00002277031,0.00003749042],"domain_scores_gemma":[0.9994203,0.0002860388,0.00007175188,0.00005123711,0.00008104472,0.00008969429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004896087,0.00003632794,0.0005421134,0.00006897745,0.000006927387,0.000101523,0.00008049882,0.0002377453,0.9944128,0.001347704,0.00007471981,0.002601106],"study_design_scores_gemma":[0.0000540204,0.0002408793,0.02036964,0.00003555247,0.00004209573,0.0008628263,0.0001323123,0.010304,0.9653628,0.0006410412,0.00191659,0.00003828341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870893,0.0008861066,0.009325713,0.0001498187,0.00004937157,0.0000203915,0.0001472664,0.00005369792,0.002278285],"genre_scores_gemma":[0.9968329,0.0002431553,0.001722409,0.00006118848,0.00000829298,0.00001230684,0.0001647518,0.00002873891,0.0009262064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003463881,"threshold_uncertainty_score":0.01158786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009253365667700398,"score_gpt":0.2165699716139572,"score_spread":0.2073166059462568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}