{"id":"W3017396921","doi":"10.1111/apt.15719","title":"Efficacy and safety of simultaneous treatment with two biologic medications in refractory Crohn’s disease","year":2020,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Medicine; Crohn's disease; Infliximab; Adalimumab; Ustekinumab; Internal medicine; Vedolizumab; Refractory (planetary science); Golimumab; Concomitant; Clinical trial; Maintenance therapy; Surgery; Gastroenterology; Cohort; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002526306,0.0002516785,0.001527349,0.0005935633,0.0002312065,0.0008347764,0.0002677798,0.0005370329,0.001240407],"category_scores_gemma":[0.006013843,0.0001749421,0.0009886322,0.0005762876,0.000442146,0.0004919511,0.0004265534,0.0006663856,0.0001780695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003775958,"about_ca_system_score_gemma":0.0002945432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001880325,"about_ca_topic_score_gemma":0.0004550408,"domain_scores_codex":[0.9980006,0.00100312,0.0003312912,0.0002583582,0.0003006305,0.0001059826],"domain_scores_gemma":[0.9906453,0.004399142,0.003639866,0.0003624054,0.0002813706,0.0006718765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.207125,0.002146854,0.4985816,0.002460956,0.006703701,0.00067548,0.0004493516,0.00129663,0.01198552,0.0001171761,0.00072954,0.2677282],"study_design_scores_gemma":[0.01916382,0.1237997,0.8363413,0.0006228127,0.005244119,0.004249675,0.0002995245,0.002362988,0.004136378,0.0002278992,0.003481886,0.00006997334],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887533,0.01025389,0.00008379139,0.0001007011,0.00001733806,0.00003423596,0.0001445333,0.00000659579,0.0006056656],"genre_scores_gemma":[0.9981633,0.001260702,0.0001678525,0.00005594106,0.00006735679,0.00003001228,0.0001770234,0.000001885233,0.0000760419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002526306,"threshold_uncertainty_score":0.01336056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796199513324832,"score_gpt":0.3002074370836827,"score_spread":0.2822454419504344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}