{"id":"W3017409551","doi":"10.1016/j.clim.2020.108428","title":"Phenotypic characterization of tumor CTLA-4 expression in melanoma tissues and its possible role in clinical response to Ipilimumab","year":2020,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Health, British Columbia; Ministero della Salute","keywords":"Ipilimumab; CTLA-4; Melanoma; Immune checkpoint; Immunotherapy; Biomarker; Cancer research; Immune system; Phenotype; Medicine; Immunology; T cell; Biology; Oncology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000214651,0.0001174729,0.0001105737,0.0005391787,0.0001767497,0.000300978,0.0001486104,0.0001973554,0.001761604],"category_scores_gemma":[0.0003833645,0.00009937602,0.0001234475,0.0002752985,0.0001301254,0.00020226,0.0001562628,0.0003082003,0.0002927065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001436123,"about_ca_system_score_gemma":0.00008624629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002693564,"about_ca_topic_score_gemma":0.0001964177,"domain_scores_codex":[0.999838,0.00005426322,0.00001517228,0.00002446299,0.00002076797,0.00004733722],"domain_scores_gemma":[0.9998448,0.00003729433,0.00003047813,0.00001786721,0.0000361007,0.00003345522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00112174,0.0001337502,0.04458481,0.00007713725,0.00002095817,0.0004194982,0.0001222774,0.0001235992,0.9443803,0.0001971281,0.0001176881,0.008701215],"study_design_scores_gemma":[0.00008759007,0.001922369,0.6775503,0.00003084051,0.0001161676,0.00381564,0.0008573465,0.004205883,0.3056623,0.0004001843,0.005335277,0.00001606492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975453,0.0003519072,0.0004896985,0.00002874977,0.000006478518,0.00001670085,0.00009748087,0.00001204291,0.001451568],"genre_scores_gemma":[0.9985604,0.0001240143,0.0003548271,0.00001931716,0.000009378577,0.00003204136,0.000177566,0.000004225813,0.0007183262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001761604,"threshold_uncertainty_score":0.005893171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0431838913839146,"score_gpt":0.3630308758169696,"score_spread":0.319846984433055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}