{"id":"W3017413818","doi":"10.1016/j.xcrm.2020.100007","title":"Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer","year":2020,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"U.S. Food and Drug Administration; Clovis Oncology; Exelixis; National Cancer Institute; AbbVie; Takeda Pharmaceuticals U.S.A.; Spectrum Pharmaceuticals; Novartis; Novartis Pharmaceuticals Corporation; Celgene; AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company; Gilead Sciences; National Institutes of Health; Medtronic","keywords":"Osimertinib; KRAS; Cancer research; Lung cancer; Adenocarcinoma; Biology; Somatic evolution in cancer; Acquired resistance; Mutation; Gene duplication; Medicine; Cancer; Gene; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003035293,0.00006734711,0.0001457912,0.000612212,0.0001788033,0.0003918452,0.0001560014,0.0002224238,0.001370104],"category_scores_gemma":[0.0006511637,0.0001014436,0.00008547503,0.0002760505,0.0001329778,0.0002808668,0.0002321968,0.0002359191,0.00015276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174138,"about_ca_system_score_gemma":0.0001099596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008031157,"about_ca_topic_score_gemma":0.002002742,"domain_scores_codex":[0.999831,0.00002548607,0.00001574375,0.00003977822,0.00004370196,0.00004426275],"domain_scores_gemma":[0.9996532,0.0001060555,0.00008919591,0.00004639632,0.0000593474,0.00004582327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005189636,0.00008736388,0.1526008,0.00004212351,0.00007526219,0.0008650915,0.0003434234,0.000876775,0.8061714,0.001033568,0.000350184,0.03703519],"study_design_scores_gemma":[0.00004096781,0.0007987905,0.8711225,0.00001828062,0.0001062086,0.009153228,0.0005704184,0.006214485,0.1049908,0.0008794651,0.006076771,0.00002794585],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981834,0.0003614446,0.0004562326,0.00003421994,0.00000303922,0.00001062438,0.00009841887,0.00001155468,0.000840911],"genre_scores_gemma":[0.9991964,0.0001248894,0.0002100285,0.00001807874,0.000003749021,0.000006752114,0.0001215856,0.000005224306,0.0003134454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001370104,"threshold_uncertainty_score":0.004583478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0163834525365052,"score_gpt":0.3125931546704295,"score_spread":0.2962097021339243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}