{"id":"W3017464623","doi":"10.1158/2326-6066.cir-18-0508","title":"Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Ontario Institute for Cancer Research","keywords":"Chimeric antigen receptor; T cell; Immunology; Immunotherapy; Adoptive cell transfer; Cytotoxic T cell; Cell therapy; Biology; T-cell receptor; Cancer research; Medicine; Immune system; Stem cell; Cell biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009373919,0.0003315497,0.0001881744,0.0001364264,0.00009837303,0.0003405941,0.0001633091,0.0002282439,0.001252992],"category_scores_gemma":[0.00007016904,0.00009514081,0.0001658062,0.0001060951,0.0001579867,0.0001684133,0.0002008009,0.0005266385,0.0005295524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001053092,"about_ca_system_score_gemma":0.0001289822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001548525,"about_ca_topic_score_gemma":0.0001775678,"domain_scores_codex":[0.9998891,0.00001441777,0.00001437998,0.00002831357,0.00002847292,0.0000252571],"domain_scores_gemma":[0.9999366,0.000006194584,0.00002007237,0.00001561399,0.000006425261,0.00001509654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002184292,0.00001408277,0.0001086183,0.00001307386,0.000002304313,0.00002048648,0.000003660246,0.00003726112,0.9988166,0.00009096287,0.00003001932,0.0008412101],"study_design_scores_gemma":[0.00001002203,0.0001939145,0.0008318916,0.00000428756,0.00002173071,0.0002311034,0.00001184023,0.0006482202,0.9939738,0.00004847855,0.004021925,0.00000268476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663385,0.001401366,0.0281561,0.0000827086,0.00009821954,0.00009646386,0.000466348,0.0002787486,0.003081499],"genre_scores_gemma":[0.9923236,0.0004688441,0.004765004,0.000045748,0.00001156554,0.00005021614,0.0003489501,0.00003013398,0.001955819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001252992,"threshold_uncertainty_score":0.004191637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09584839896265963,"score_gpt":0.3678044325559333,"score_spread":0.2719560335932737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}