{"id":"W3017473937","doi":"10.3390/app10082872","title":"Optimising Hydrogel Release Profiles for Viro-Immunotherapy Using Oncolytic Adenovirus Expressing IL-12 and GM-CSF with Immature Dendritic Cells","year":2020,"lang":"en","type":"article","venue":"Applied Sciences","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Australian Research Council","keywords":"Oncolytic virus; Immune system; Immunotherapy; Virotherapy; Cancer immunotherapy; Self-healing hydrogels; Dendritic cell; Oncolytic adenovirus; Cancer research; Biology; Immunology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004021906,0.0002352789,0.0002266549,0.0001945293,0.000118593,0.0005079289,0.0002416027,0.0003376162,0.0002980198],"category_scores_gemma":[0.0007565929,0.000166827,0.0003429966,0.0001553477,0.0002466342,0.0002985658,0.0002089118,0.0003499318,0.00008980239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007131002,"about_ca_system_score_gemma":0.0004975816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001353981,"about_ca_topic_score_gemma":0.001172746,"domain_scores_codex":[0.999893,0.00001621364,0.00001045574,0.00002301647,0.00004105845,0.00001634735],"domain_scores_gemma":[0.9998127,0.00008868345,0.00005757972,0.00001076045,0.0000226363,0.000007744877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001477217,0.0001080685,0.001184482,0.0001887538,0.00001670241,0.000116998,0.00009857088,0.4036087,0.584885,0.001889337,0.0001022237,0.007653386],"study_design_scores_gemma":[0.00003047772,0.000186002,0.0004775385,0.00001077127,0.00001485142,0.00003553603,0.00002784837,0.7224656,0.2757882,0.0002768643,0.0006649041,0.00002137582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8950549,0.0003746077,0.1027305,0.0001281455,0.00002227729,0.00007241721,0.0001325814,0.0001194968,0.001365023],"genre_scores_gemma":[0.964954,0.0002944567,0.03394419,0.00001465643,0.000002180902,0.00005072182,0.00005167307,0.00001943898,0.0006687186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001353981,"threshold_uncertainty_score":0.005173862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03155364784677581,"score_gpt":0.2930262164776249,"score_spread":0.2614725686308491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}