{"id":"W3017580933","doi":"10.1038/s41398-020-0793-y","title":"Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling","year":2020,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Hospital for Sick Children; University of Toronto","funders":"FP7 People: Marie-Curie Actions; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; Alberta Innovates; Innovative Medicines Initiative; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Mental Health; European Federation of Pharmaceutical Industries and Associations; Children's Hospital of Philadelphia","keywords":"Genome-wide association study; Population; Cohort; Insulin; Etiology; Insulin receptor; Genetic epidemiology; Medicine; Genetic association; Psychiatry; Psychology; Bioinformatics; Genetics; Single-nucleotide polymorphism; Insulin resistance; Internal medicine; Biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002502758,0.0006751452,0.000819427,0.0003150348,0.0004225387,0.0001319678,0.0008679694,0.00040613,0.0008291467],"category_scores_gemma":[0.00008717606,0.0006085464,0.0002712928,0.001169814,0.0003564373,0.0003567325,0.00006498223,0.0009853358,0.0001899474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004113834,"about_ca_system_score_gemma":0.0001578365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003712638,"about_ca_topic_score_gemma":0.0002389206,"domain_scores_codex":[0.995295,0.0007563622,0.001236943,0.001318616,0.0006048335,0.0007882032],"domain_scores_gemma":[0.9976432,0.0009474296,0.0005225461,0.000486207,0.0001387758,0.0002618569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003013015,0.0002478824,0.9581745,0.00007219039,0.0002694016,0.00002439883,0.007886793,0.002803596,0.0000326716,0.02206992,0.000357542,0.007759808],"study_design_scores_gemma":[0.004984075,0.0003045062,0.957764,0.00007305256,0.0001572813,0.00002839297,0.002839374,0.0008272096,0.0000020214,0.03206152,0.000289431,0.0006691503],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576085,0.007967092,0.006000357,0.02465899,0.000932203,0.0014789,0.0002847528,0.0001575178,0.0009117272],"genre_scores_gemma":[0.9912759,0.00004487724,0.003360984,0.003164308,0.0009898311,0.0001461061,0.0009067082,0.00009859203,0.00001270761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03366742,"threshold_uncertainty_score":0.9996366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781809500559422,"score_gpt":0.2834498064791329,"score_spread":0.2656317114735387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}