{"id":"W3017742258","doi":"10.22215/etd/2019-13952","title":"Analysis of Differences Between Human Alternative Splicing Protein Isoforms and Their Links to Diseases","year":2019,"lang":"en","type":"dissertation","venue":"","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Gene isoform; Alternative splicing; Protein isoform; RNA splicing; Computational biology; Biology; Mirroring; Proteome; Genetics; Bioinformatics; Gene; Psychology; Communication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004513773,0.0002486449,0.000234474,0.001099785,0.0002555925,0.0005202591,0.0001410184,0.0002397954,0.001712892],"category_scores_gemma":[0.0008320069,0.0001019697,0.000507699,0.001202677,0.0001274541,0.0002464033,0.0003757302,0.0003500993,0.000561782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479827,"about_ca_system_score_gemma":0.0002387586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009384942,"about_ca_topic_score_gemma":0.001260222,"domain_scores_codex":[0.9996942,0.00003557211,0.00002074851,0.0001477542,0.00006851566,0.00003319507],"domain_scores_gemma":[0.9995574,0.0001890928,0.0001277641,0.00002869208,0.00005487882,0.00004213616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001285673,0.0001557492,0.7580382,0.0005881822,0.0006810836,0.0008832347,0.0002689673,0.005521159,0.1214877,0.001123965,0.004921186,0.1050448],"study_design_scores_gemma":[0.00002133022,0.0001981926,0.9520169,0.00004887741,0.0002981632,0.001052088,0.0001982906,0.01833621,0.01756349,0.001847664,0.008396968,0.00002186832],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9722117,0.002465964,0.006654748,0.0002839088,0.00002615913,0.00002485219,0.01558545,0.0001969432,0.002550179],"genre_scores_gemma":[0.9661583,0.001436524,0.00920555,0.0001080283,0.00002651748,0.00004310933,0.02151763,0.00004529372,0.001458989],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001712892,"threshold_uncertainty_score":0.005730212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01565757202642254,"score_gpt":0.3090617426960207,"score_spread":0.2934041706695981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}