{"id":"W3017812764","doi":"10.1101/2020.04.24.057802","title":"Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada)","funders":"","keywords":"Temozolomide; Glioma; Medicine; Personalized medicine; Brain tumor; Cancer research; Precision medicine; Epigenetics; Oncology; Bioinformatics; Pathology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003976526,0.0003902294,0.0002989698,0.0002584301,0.0001648882,0.0004700157,0.000167424,0.0003217981,0.002625522],"category_scores_gemma":[0.0001371456,0.0001341614,0.0002338144,0.0002055491,0.0002084494,0.0002459689,0.0003335913,0.0009213248,0.0007769961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002068885,"about_ca_system_score_gemma":0.0002082833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003762649,"about_ca_topic_score_gemma":0.0006350998,"domain_scores_codex":[0.9998043,0.00004142893,0.00001704256,0.00004093671,0.00006252015,0.00003371156],"domain_scores_gemma":[0.9998789,0.00002226053,0.00002624794,0.00002801448,0.00001410119,0.00003058842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003568901,0.000161731,0.001118043,0.00006304654,0.0000235093,0.0001995484,0.00005911236,0.0003615377,0.9905985,0.0009439572,0.0009235554,0.005190585],"study_design_scores_gemma":[0.00006670991,0.001036433,0.005686699,0.00001462919,0.00005462106,0.00175851,0.0000931547,0.00249299,0.9630647,0.0003341035,0.02538434,0.00001323687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537262,0.001385358,0.03164826,0.0002937621,0.0001791246,0.0002866587,0.005257376,0.0004224945,0.006800711],"genre_scores_gemma":[0.9553701,0.001524209,0.0234795,0.0001635338,0.00003210135,0.0002470839,0.00912203,0.0001775335,0.009883851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002625522,"threshold_uncertainty_score":0.008783281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02295325086063282,"score_gpt":0.2485088913330093,"score_spread":0.2255556404723765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}