{"id":"W3017890102","doi":"10.1109/jbhi.2020.2984355","title":"Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines","year":2020,"lang":"en","type":"article","venue":"IEEE Journal of Biomedical and Health Informatics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; Biogen; BioClinica; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Engineering and Physical Sciences Research Council; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Alzheimer's Association; Horizon 2020 Framework Programme; Foundation for the National Institutes of Health","keywords":"Disease; Biomarker; Support vector machine; Feature selection; Computer science; Amyloid beta; Machine learning; Alzheimer's disease; Apolipoprotein E; Medicine; Artificial intelligence; Bioinformatics; Computational biology; Pathology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001655169,0.001084251,0.0009209395,0.001339711,0.0001763924,0.0007072797,0.0004682051,0.0006695093,0.0005393557],"category_scores_gemma":[0.003057636,0.0002022916,0.0007381873,0.0006919605,0.0001962464,0.0007676368,0.0003884092,0.0007810486,0.0003995101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003134126,"about_ca_system_score_gemma":0.0004357435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001315144,"about_ca_topic_score_gemma":0.0009862882,"domain_scores_codex":[0.9993203,0.0002166254,0.00005782948,0.0001593671,0.0001509656,0.00009506405],"domain_scores_gemma":[0.9987873,0.000687537,0.0001752296,0.00005579052,0.0002347825,0.00005923783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001276681,0.0006962332,0.0623089,0.0003167481,0.0003210181,0.0004041804,0.0001407378,0.1315761,0.05644808,0.001219259,0.003904294,0.7413878],"study_design_scores_gemma":[0.00001593673,0.0002044622,0.007743167,0.00001914186,0.00003585439,0.00009272529,0.000029716,0.9804595,0.00986913,0.000946435,0.000559594,0.00002441634],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5057135,0.002689212,0.4862062,0.0004757584,0.0001988408,0.0001615543,0.0004886612,0.002564711,0.001501488],"genre_scores_gemma":[0.9146779,0.0003648462,0.08386346,0.0000789168,0.00005050328,0.00007241357,0.0002998135,0.00001943621,0.0005727331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655169,"threshold_uncertainty_score":0.008753538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05468688520294072,"score_gpt":0.3336398252890928,"score_spread":0.278952940086152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}