{"id":"W3017901522","doi":"10.1016/j.joca.2020.02.173","title":"Generation of an inducible tissue specific DIO2 overexpression mouse","year":2020,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"DIO2; Cre recombinase; Iodothyronine deiodinase; Biology; Knockout mouse; Genetically modified mouse; Transgene; Cartilage; Cell biology; Endocrinology; Genetics; Deiodinase; Gene; Thyroid; Anatomy; Triiodothyronine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007365492,0.001010101,0.0005694472,0.001671185,0.0005641018,0.0007982658,0.0009924439,0.001262476,0.007432892],"category_scores_gemma":[0.0002641769,0.0008719629,0.0007301387,0.0007132364,0.0005950661,0.0006271829,0.0006166188,0.002208547,0.003268293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005684168,"about_ca_system_score_gemma":0.0004454668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007826322,"about_ca_topic_score_gemma":0.001908573,"domain_scores_codex":[0.999266,0.00004656236,0.00009826784,0.0002328864,0.0002129018,0.0001433999],"domain_scores_gemma":[0.9994573,0.00006678684,0.0001573847,0.00006607621,0.0000566851,0.0001956849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002002403,0.0001231238,0.0002396161,0.00008893223,0.00001637785,0.000171996,0.00004076479,0.00009416166,0.995447,0.00122413,0.0005860807,0.001767585],"study_design_scores_gemma":[0.0002192659,0.0002465036,0.003080889,0.0000389981,0.00009494871,0.0009166351,0.0001205863,0.002046473,0.9540165,0.0003029317,0.0388932,0.00002304182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8015009,0.004005597,0.1297163,0.002502959,0.002268317,0.001743151,0.03364138,0.002623736,0.02199772],"genre_scores_gemma":[0.7839941,0.004157614,0.05684896,0.001294663,0.0002942437,0.002665007,0.02333974,0.001344177,0.1260615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007432892,"threshold_uncertainty_score":0.02486545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05542409646808109,"score_gpt":0.2804036468923934,"score_spread":0.2249795504243124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}