{"id":"W3017901522","doi":"10.1016/j.joca.2020.02.173","title":"Generation of an inducible tissue specific DIO2 overexpression mouse","year":2020,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"DIO2; Cre recombinase; Iodothyronine deiodinase; Biology; Knockout mouse; Genetically modified mouse; Transgene; Cartilage; Cell biology; Endocrinology; Genetics; Deiodinase; Gene; Thyroid; Anatomy; Triiodothyronine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004670909,0.00008813385,0.000186875,0.00003305838,0.00006239739,0.00002722395,0.0000279282,0.00005577133,0.0004484018],"category_scores_gemma":[0.00002102355,0.00008142396,0.00003857795,0.00007814678,0.00003300922,0.000156681,0.00002329318,0.00009953875,0.00001295465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007020374,"about_ca_system_score_gemma":0.0000175766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008604863,"about_ca_topic_score_gemma":0.000008759185,"domain_scores_codex":[0.9993217,0.00002530669,0.0001983331,0.0002148275,0.0001374283,0.0001024282],"domain_scores_gemma":[0.9995583,0.000007860617,0.00005422985,0.0001570861,0.00005763231,0.000164902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005771318,0.00004335073,0.0001006933,0.00002280507,0.00000122286,0.00001695273,0.0004805753,0.000005031002,0.9823273,0.0001067262,0.001421917,0.01541565],"study_design_scores_gemma":[0.0008783033,0.001427297,0.0001001038,0.00008317626,0.00001175163,0.00003533251,0.0001830078,0.00008054729,0.9654048,0.000005915188,0.03171343,0.00007630912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965958,0.0006982443,0.00007013173,0.0003139462,0.00006590177,0.0001666269,0.00005237676,0.00003237223,0.002004628],"genre_scores_gemma":[0.998495,0.0001193652,0.0003895542,0.0002758321,0.0004272543,0.000007862684,0.00009140742,0.00001580478,0.0001779063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03029152,"threshold_uncertainty_score":0.4909686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05542409646808109,"score_gpt":0.2804036468923934,"score_spread":0.2249795504243124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}