{"id":"W3018070323","doi":"10.1096/fasebj.2020.34.s1.03475","title":"Novel Therapeutic Opportunities for Diabetic Complications using a Small Molecule Antagonist of RAGE/DIAPH1 Interaction","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"","keywords":"In vivo; Rage (emotion); Ischemia; Pharmacology; Ex vivo; Antagonist; Medicine; Receptor; Chemistry; Internal medicine; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761619,0.00007459628,0.00008475716,0.00002786881,0.0001896283,0.00002974618,0.000209574,0.0000289252,0.00001188838],"category_scores_gemma":[0.0001060468,0.00005786231,0.00006884645,0.0000689997,0.0001007055,0.000006506722,0.00004600036,0.0001239176,8.968019e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001336914,"about_ca_system_score_gemma":0.0001193334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002967884,"about_ca_topic_score_gemma":0.000001123578,"domain_scores_codex":[0.9994105,0.00005998225,0.000187991,0.0001179407,0.00008764005,0.0001360216],"domain_scores_gemma":[0.9993543,0.00003384988,0.0001533668,0.0001711213,0.0002165222,0.00007085255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008677587,0.00003240156,0.00004293286,0.00001782773,0.00005062353,3.895799e-7,0.0001050393,0.001138921,0.9956943,0.0001538963,0.00007201985,0.002604844],"study_design_scores_gemma":[0.0004332852,0.0001963435,0.0001325153,0.00001342375,0.00003171971,0.00009138214,0.0008345417,0.003691233,0.9892885,0.0001346035,0.005066261,0.00008620437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5519374,0.0005019847,0.4416969,0.005207209,0.00008704235,0.0002654364,0.00005820495,0.000005642535,0.0002402408],"genre_scores_gemma":[0.9955082,0.0001449514,0.003269354,0.0007046465,0.0002114655,0.00001046702,0.0000422932,0.0000163838,0.00009226996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4435708,"threshold_uncertainty_score":0.2359557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1780081173632418,"score_gpt":0.3539056856100085,"score_spread":0.1758975682467667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}