{"id":"W3018138064","doi":"10.1053/j.gastro.2020.04.039","title":"Attribution of Nonalcoholic Steatohepatitis as an Etiology of Cirrhosis for Clinical Trials Eligibility: Recommendations From the Multi-stakeholder Liver Forum","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Allos Therapeutics; Genentech; Ferring Pharmaceuticals; Novo Nordisk; Intercept Pharmaceuticals; School of Medicine, Indiana University; Novartis Pharma; University of Alberta; Inselspital, Universitätsspital Bern; Cirius Therapeutics; European Medicines Agency; Bundesinstitut für Arzneimittel und Medizinprodukte; Zafgen; U.S. Food and Drug Administration; Government of South Australia; Allergan; AstraZeneca; Amarin Corporation; Valeant Pharmaceuticals International; University of Bern; Takeda Pharmaceuticals U.S.A.; EA Pharma Co., Ltd.; Virginia Commonwealth University; Gilead Sciences; Yale University; Novartis; Coherus Biosciences; Arrowhead Pharmaceuticals; CymaBay Therapeutics; Merck; GlaxoSmithKline; NGM Biopharmaceuticals; Exact Sciences Corporation; Bristol-Myers Squibb; Eli Lilly and Company; Abbott Laboratories; Boehringer Ingelheim; Inventiva Pharma; U.S. Department of Health and Human Services; Salix Pharmaceuticals; Pfizer; Galectin Therapeutics; Shire; Novartis Pharmaceuticals Corporation","keywords":"Nonalcoholic steatohepatitis; Cirrhosis; Medicine; Steatohepatitis; Gastroenterology; Internal medicine; Stakeholder; Clinical trial; Etiology; Nonalcoholic fatty liver disease; Fatty liver; Political science; Public relations","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008031018,0.0001400165,0.0008711516,0.00003255918,0.0000480227,0.000004092984,0.0001262377,0.0001258441,0.0003411931],"category_scores_gemma":[0.001006609,0.00009776164,0.0004290725,0.000054211,0.0001881886,0.00004998425,0.00006170766,0.0001177798,0.00001033972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003014213,"about_ca_system_score_gemma":0.00006982484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003557845,"about_ca_topic_score_gemma":0.0003083676,"domain_scores_codex":[0.997223,0.00105718,0.00101295,0.0003763533,0.0001000821,0.000230388],"domain_scores_gemma":[0.9975189,0.001289259,0.000463789,0.0003315173,0.0002166109,0.0001799413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002436246,0.001431583,0.9849132,0.00002483008,0.0008006392,0.00000341209,0.0003190729,0.000001708583,0.0002063943,0.0001871597,0.003632001,0.006043703],"study_design_scores_gemma":[0.009015528,0.006238091,0.9800243,0.00003729244,0.001261394,0.000004822131,0.0003082337,0.0004657051,0.0005398359,0.0001270646,0.001929688,0.0000480364],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670875,0.000198291,0.004240235,0.02452285,0.0001747142,0.001224827,0.002531597,0.00001659765,0.000003391236],"genre_scores_gemma":[0.9884179,0.0007206055,0.00224887,0.006757767,0.0001628316,0.0002032887,0.001472562,0.00001301971,0.000003164364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0213304,"threshold_uncertainty_score":0.3986604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4146672467596223,"score_gpt":0.4777769667719389,"score_spread":0.06310972001231663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}