{"id":"W3018410811","doi":"10.1083/jcb.201909165","title":"Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress","year":2020,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Nanyang Technological University; National Research Foundation Singapore","keywords":"Unfolded protein response; Endoplasmic reticulum; Cell biology; Transmembrane protein; Lipid metabolism; Biology; Mutant; Membrane protein; Chemistry; Biochemistry; Gene; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474875,0.0003112823,0.000312988,0.0002004734,0.0001461065,0.0003524396,0.0001634485,0.0002640694,0.0003932654],"category_scores_gemma":[0.0001181549,0.0001610748,0.0001893323,0.0001104396,0.0003116493,0.0002530927,0.0004493893,0.0006403414,0.0002611196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998315,"about_ca_system_score_gemma":0.0001682132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001954153,"about_ca_topic_score_gemma":0.0003253713,"domain_scores_codex":[0.9998755,0.00000952617,0.000008829134,0.0000435488,0.00003749125,0.00002494842],"domain_scores_gemma":[0.999889,0.00001258302,0.00003399132,0.00001468498,0.00002165777,0.00002807312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003300366,0.000005572805,0.0001423821,0.000006901251,7.279119e-7,0.00001926938,0.000005297093,0.00003491943,0.9994246,0.00004475196,0.000008033768,0.0002745534],"study_design_scores_gemma":[0.00001310971,0.0001339111,0.01784497,0.000009631104,0.0000110389,0.0004006992,0.0000832383,0.00279623,0.9774516,0.0001684876,0.001072389,0.00001465261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953524,0.0004285767,0.00310965,0.00009839455,0.00001492423,0.00001724734,0.000255915,0.0001005788,0.000622288],"genre_scores_gemma":[0.994042,0.0003303619,0.003486593,0.0001344213,0.00000666511,0.00002904021,0.0005844788,0.00003199649,0.001354586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003932654,"threshold_uncertainty_score":0.002175391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387862989373017,"score_gpt":0.2601257276282681,"score_spread":0.246247097734538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}