{"id":"W3018744657","doi":"10.1101/2020.04.22.054684","title":"Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Max-Planck-Institut für Bildungsforschung; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft","keywords":"PRC2; EZH2; Histone H3; Chromatin; Nucleosome; Histone methylation; Cell biology; Biology; Chemistry; Genetics; DNA; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006471619,0.0001975761,0.0001454852,0.00006828696,0.0003304195,0.0003025903,0.0003242952,0.0003087122,0.004584458],"category_scores_gemma":[0.0001457978,0.0001762714,0.0001897576,0.00006792902,0.0002746209,0.0001920355,0.0002381127,0.0004984765,0.001191447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005312088,"about_ca_system_score_gemma":0.0003051799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001862423,"about_ca_topic_score_gemma":0.001660765,"domain_scores_codex":[0.9999515,0.000003879847,0.000002553087,0.00001428969,0.00001614407,0.00001175669],"domain_scores_gemma":[0.9999472,0.000006579095,0.00001166971,0.000009232192,0.000007683266,0.00001763596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001636749,0.00002182763,0.00078197,0.00004874498,0.0000100806,0.0001673501,0.00002339954,0.001206596,0.9924319,0.003145273,0.000388939,0.001610317],"study_design_scores_gemma":[0.00005329676,0.00006569244,0.00712308,0.000007988269,0.00001061213,0.0002536608,0.00004179204,0.0176254,0.9674113,0.001410412,0.005985497,0.00001136987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638962,0.001088498,0.02093115,0.0006310406,0.0001454309,0.00002834462,0.0007570701,0.0006086656,0.01191349],"genre_scores_gemma":[0.9932086,0.0001273711,0.003330015,0.00005654717,0.000008396807,0.000007906425,0.0004166233,0.0000395434,0.002804955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004584458,"threshold_uncertainty_score":0.01533657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107974934918149,"score_gpt":0.2687439721216588,"score_spread":0.2476642227724773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}