{"id":"W3018816769","doi":"10.1096/fasebj.2020.34.s1.09569","title":"Unfolding the Mysteries of Oxygen Sensing ‐ A Comprehensive Analysis of the Hypoxic Response in Zebrafish Gills One Cell at a Time via Single Cell RNA Sequencing","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Zebrafish; Biology; Danio; Transcriptome; Gill; Cell biology; Hypoxia (environmental); Single-cell analysis; Cell; Chemoreceptor; Gene; Anatomy; Gene expression; Genetics; Oxygen; Chemistry; Fish <Actinopterygii>; Fishery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359022,0.0004102194,0.0004185598,0.0003432388,0.0004069488,0.0004268963,0.0003081949,0.0005131197,0.0006765085],"category_scores_gemma":[0.0002567973,0.0002921576,0.0003517554,0.0002539198,0.0006486006,0.000742717,0.0003707648,0.0006392545,0.000205296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004749315,"about_ca_system_score_gemma":0.0005282636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002921974,"about_ca_topic_score_gemma":0.008167261,"domain_scores_codex":[0.9998693,0.000007592488,0.000007020384,0.00004401239,0.00005189346,0.00002017723],"domain_scores_gemma":[0.9998827,0.00002021609,0.00002709591,0.0000129601,0.00003800319,0.00001907832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003166977,0.000002793077,0.0008944136,0.00008603484,0.000009563411,0.00004393253,0.00009754261,0.0002221969,0.9925697,0.0002837405,0.0001981694,0.005560143],"study_design_scores_gemma":[0.00003471619,0.0007890419,0.3183719,0.0003340158,0.0002685169,0.001175819,0.001667837,0.01536613,0.5843485,0.007152789,0.07030074,0.0001899305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9180801,0.01612978,0.05255286,0.00258388,0.0001971179,0.0001006828,0.00556263,0.0005329212,0.004260116],"genre_scores_gemma":[0.9165388,0.01689146,0.05349494,0.001918328,0.0001642412,0.0001752005,0.004173937,0.0002691795,0.006373805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002921974,"threshold_uncertainty_score":0.005809963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02578014915423463,"score_gpt":0.2477738515492348,"score_spread":0.2219937023950002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}