{"id":"W3018862202","doi":"10.1016/j.wneu.2020.04.087","title":"Severe Radiation Necrosis Refractory to Surgical Resection in Patients with Melanoma and Brain Metastases Managed with Ipilimumab/Nivolumab and Brain-Directed Stereotactic Radiation Therapy","year":2020,"lang":"en","type":"article","venue":"World Neurosurgery","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Advanced Cyberinfrastructure; Bristol-Myers Squibb Canada; Novartis; Regeneron Pharmaceuticals; Varian Medical Systems; Genentech; Merck","keywords":"Medicine; Ipilimumab; Nivolumab; Refractory (planetary science); Radiosurgery; Radiation therapy; Melanoma; Stereotactic radiation therapy; Radiology; Surgery; Immunotherapy; Internal medicine; Cancer; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002613917,0.0002882026,0.0004908764,0.0003933756,0.0001169357,0.00008301094,0.00003537495,0.00004779242,0.00005250471],"category_scores_gemma":[0.0001859316,0.0002194153,0.0000489622,0.0009336874,0.00005488138,0.0002649873,0.00002755598,0.0002360988,0.000003374645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009398765,"about_ca_system_score_gemma":0.00005294353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001132222,"about_ca_topic_score_gemma":0.0001662486,"domain_scores_codex":[0.9979505,0.0004337058,0.0003350631,0.0006156996,0.0003708453,0.0002941967],"domain_scores_gemma":[0.9984595,0.0007782097,0.0001632026,0.0002332095,0.00005576212,0.0003101374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0216237,0.0006383965,0.8912139,0.0001183874,0.0002637747,0.0005146832,0.0005371138,0.00004462062,0.000289118,0.00001761559,0.004963346,0.07977533],"study_design_scores_gemma":[0.01184856,0.002976071,0.9674205,0.0000890951,0.00009608618,0.0000443062,0.00002801724,0.0001262601,0.0002640447,0.000003834149,0.01684401,0.0002592856],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888552,0.0003921153,0.000006854499,0.009397199,0.00006966065,0.001062644,0.00004130118,0.0001013302,0.00007372408],"genre_scores_gemma":[0.9952957,0.0001411803,0.0001310677,0.003860044,0.00006530388,0.0000596683,0.0001650117,0.00005440167,0.0002276469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07951605,"threshold_uncertainty_score":0.8947498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488971103582913,"score_gpt":0.236190891367843,"score_spread":0.2213011803320138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}