{"id":"W3018862202","doi":"10.1016/j.wneu.2020.04.087","title":"Severe Radiation Necrosis Refractory to Surgical Resection in Patients with Melanoma and Brain Metastases Managed with Ipilimumab/Nivolumab and Brain-Directed Stereotactic Radiation Therapy","year":2020,"lang":"en","type":"article","venue":"World Neurosurgery","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Advanced Cyberinfrastructure; Bristol-Myers Squibb Canada; Novartis; Regeneron Pharmaceuticals; Varian Medical Systems; Genentech; Merck","keywords":"Medicine; Ipilimumab; Nivolumab; Refractory (planetary science); Radiosurgery; Radiation therapy; Melanoma; Stereotactic radiation therapy; Radiology; Surgery; Immunotherapy; Internal medicine; Cancer; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002160419,0.0003887752,0.0005520823,0.0004915644,0.0007981666,0.0007190319,0.0002681702,0.0004735328,0.001125474],"category_scores_gemma":[0.001096107,0.0002360775,0.000582077,0.0004749018,0.0004270035,0.0003670784,0.0004004259,0.0006490345,0.0001618468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006323445,"about_ca_system_score_gemma":0.0007751955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009542878,"about_ca_topic_score_gemma":0.002547333,"domain_scores_codex":[0.9997749,0.00004137449,0.00002847054,0.00003082562,0.0000342547,0.00009028921],"domain_scores_gemma":[0.9995554,0.00007363458,0.0001403814,0.00001534561,0.000018801,0.0001963941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.003535643,0.0003813278,0.7584446,0.0001741599,0.0003366211,0.2061847,0.0003554292,0.001041515,0.008632495,0.0003463711,0.002009641,0.01855762],"study_design_scores_gemma":[0.0002016521,0.001718262,0.6932521,0.00006455044,0.0002199854,0.2982394,0.0007205264,0.001799936,0.0009727423,0.0006150269,0.002157929,0.00003780204],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944108,0.001425687,0.0002058557,0.0006207949,0.00004374399,0.00003233191,0.00007318666,0.00001180708,0.003175742],"genre_scores_gemma":[0.9991935,0.0002511119,0.00007276708,0.0001946392,0.0000675923,0.000006056978,0.00008378538,0.000003460997,0.0001271751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125474,"threshold_uncertainty_score":0.004588008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488971103582913,"score_gpt":0.236190891367843,"score_spread":0.2213011803320138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}