{"id":"W3018878465","doi":"10.1038/s41467-020-15941-2","title":"Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Alberta Children's Hospital; University of Calgary; Hospital for Sick Children","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research; Scottish Rite Charitable Foundation of Canada; Government of Canada; Ontario Brain Institute","keywords":"Methylglyoxal; Cell biology; Notch signaling pathway; Translation (biology); Glyceraldehyde 3-phosphate dehydrogenase; Biology; Neural stem cell; Biochemistry; Gene expression; Signal transduction; Messenger RNA; Stem cell; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876685,0.0002101911,0.0001477962,0.0001305214,0.0001485973,0.000318112,0.0001848376,0.0001591975,0.0006083623],"category_scores_gemma":[0.0001264201,0.0001577022,0.0001865871,0.0000900146,0.000256003,0.0002000535,0.0002530186,0.0002361151,0.0002009701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266394,"about_ca_system_score_gemma":0.0002214553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005189961,"about_ca_topic_score_gemma":0.001390753,"domain_scores_codex":[0.9998353,0.0000341879,0.00001376003,0.00004656045,0.00005360354,0.00001665318],"domain_scores_gemma":[0.9999236,0.00001205298,0.00002946095,0.00001015729,0.000009814789,0.00001498393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003825039,0.000001962414,0.0001498172,0.00001220612,0.000001833468,0.0000160145,0.00000670718,0.00004946845,0.9988235,0.0001238617,0.000008853688,0.0007676341],"study_design_scores_gemma":[0.000003903151,0.00005626289,0.003611793,0.000002528984,0.000006354549,0.00006985216,0.00001762375,0.000607563,0.9941023,0.00009065778,0.0014281,0.000003029723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903252,0.002263833,0.005169523,0.0001252095,0.0000281454,0.00001240613,0.0002370572,0.00007236905,0.001766234],"genre_scores_gemma":[0.9937857,0.0009348145,0.002883895,0.00005925518,0.00001041287,0.0000128521,0.0002961491,0.00002214194,0.00199474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006083623,"threshold_uncertainty_score":0.002369881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466645232177099,"score_gpt":0.295622920236439,"score_spread":0.270956467914668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}