{"id":"W3019030237","doi":"10.1371/journal.pone.0231942","title":"Putting the microbiota to work: Epigenetic effects of early life antibiotic treatment are associated with immune-related pathways and reduced epithelial necrosis following Salmonella Typhimurium challenge in vitro","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"Genome Canada","keywords":"Biology; Microbiology; Salmonella; Salmonella enterica; Microbiome; Explant culture; Immune system; Amoxicillin; Antibiotics; In vivo; Ex vivo; In vitro; Immunology; Bacteria; Biotechnology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830684,0.0001553447,0.0003363893,0.0001401757,0.0001541608,0.0003820081,0.0001028055,0.000294011,0.002189467],"category_scores_gemma":[0.000224876,0.0001520384,0.0003392207,0.0001037641,0.0002876864,0.0002054727,0.0002189142,0.0006142741,0.000311366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693793,"about_ca_system_score_gemma":0.0001817947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004253711,"about_ca_topic_score_gemma":0.0008493092,"domain_scores_codex":[0.9997979,0.00003654665,0.00001040218,0.0000655317,0.00003518145,0.00005458872],"domain_scores_gemma":[0.9998657,0.00002099915,0.00004544459,0.00001553771,0.00002392032,0.00002838193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001006547,0.0001129675,0.002083577,0.0001072861,0.00002328433,0.0000776673,0.0001449315,0.000033314,0.9910769,0.00005525487,0.0001492802,0.005128866],"study_design_scores_gemma":[0.0000976686,0.00627349,0.2961307,0.0001042944,0.000197463,0.0004927475,0.001281302,0.0008966443,0.6838217,0.0003949255,0.01026818,0.00004087922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940385,0.002576152,0.001050625,0.000282301,0.0001273818,0.00001962186,0.0006071299,0.00004252687,0.001255736],"genre_scores_gemma":[0.9943628,0.001481827,0.0006678824,0.0003009934,0.00002315898,0.00006406418,0.0003838693,0.00001949588,0.002695872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002189467,"threshold_uncertainty_score":0.007324457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02278552574060258,"score_gpt":0.2075226785438102,"score_spread":0.1847371528032076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}