{"id":"W3019561960","doi":"10.1093/nar/gkaa281","title":"High specificity and tight spatial restriction of self-biotinylation by DNA and RNA G-Quadruplexes complexed in vitro and in vivo with Heme","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Biotinylation; DNA; In vitro; RNA; In vivo; Heme; Molecular biology; Genetics; Biochemistry; Cell biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002379686,0.0002268651,0.0001599432,0.0001180403,0.000101526,0.0002743066,0.0002203703,0.0002455972,0.0005761822],"category_scores_gemma":[0.000344928,0.0002230956,0.0001178547,0.00007229693,0.0003469976,0.0001812634,0.0002503225,0.0003997457,0.0002989603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511899,"about_ca_system_score_gemma":0.0001574776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005694955,"about_ca_topic_score_gemma":0.001270707,"domain_scores_codex":[0.9997919,0.00004255202,0.00001134142,0.00007701288,0.00005076604,0.00002646253],"domain_scores_gemma":[0.9997702,0.00009373394,0.00004468605,0.00002887405,0.00002754871,0.00003495914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008061912,0.000001593326,0.00002399396,0.000007471796,9.826123e-7,0.000003515999,0.000008539335,0.00002101513,0.9996554,0.00003265965,0.000002444009,0.0002342913],"study_design_scores_gemma":[0.000002706721,0.00003637277,0.000485087,0.000001117917,0.000002118011,0.00004091419,0.000006110046,0.000320873,0.9987211,0.00001838656,0.0003636125,0.000001479939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790173,0.0007261951,0.01883691,0.00006974868,0.00001038584,0.00002954748,0.00008561726,0.0001048237,0.001119409],"genre_scores_gemma":[0.9922134,0.000181016,0.005822822,0.00002423682,0.000002972545,0.0000224743,0.000133023,0.00003426411,0.001565764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005761822,"threshold_uncertainty_score":0.001927495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01898614030155224,"score_gpt":0.2667121278337216,"score_spread":0.2477259875321694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}