{"id":"W3019561960","doi":"10.1093/nar/gkaa281","title":"High specificity and tight spatial restriction of self-biotinylation by DNA and RNA G-Quadruplexes complexed in vitro and in vivo with Heme","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Biotinylation; DNA; In vitro; RNA; In vivo; Heme; Molecular biology; Genetics; Biochemistry; Cell biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002232518,0.00009689174,0.0001634778,0.00007500983,0.00007591044,0.00001942508,0.00005565234,0.0001558879,0.000006989568],"category_scores_gemma":[0.00004824188,0.0000796767,0.000009693564,0.0002094717,0.0002496693,0.000006225213,0.0001377254,0.0002306962,3.924956e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001370867,"about_ca_system_score_gemma":0.00002077833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003575928,"about_ca_topic_score_gemma":0.000124102,"domain_scores_codex":[0.9990444,0.0001156289,0.0001662178,0.0003078173,0.0001762253,0.0001897067],"domain_scores_gemma":[0.9997197,0.00002921264,0.0000381008,0.00008463833,0.00005969075,0.00006869806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006546847,0.00005093161,0.01760851,0.00005914697,0.00002226775,0.000003357572,0.0002976464,0.000002002677,0.9796611,0.00002904811,0.0005424963,0.001068829],"study_design_scores_gemma":[0.001695976,0.0006138282,0.1137377,0.0000299695,0.000006721172,0.000003929521,0.0003835764,0.0008465722,0.880827,0.0000487726,0.001664547,0.0001413643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976572,0.0008503329,0.00003041593,0.0009242605,0.00001301615,0.0002069,0.00002534612,0.00000644274,0.0002860518],"genre_scores_gemma":[0.9970124,0.002327279,0.0005226551,0.00002287955,0.00005278146,0.000003348204,0.00002130076,0.00001049514,0.00002690683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09883407,"threshold_uncertainty_score":0.3249122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01898614030155224,"score_gpt":0.2667121278337216,"score_spread":0.2477259875321694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}