{"id":"W3019565062","doi":"10.1038/s41416-020-0834-6","title":"Emerging role of PTEN loss in evasion of the immune response to tumours","year":2020,"lang":"en","type":"review","venue":"British Journal of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministério da Ciência, Tecnologia e Inovação; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"PTEN; PI3K/AKT/mTOR pathway; Immune system; Immunotherapy; Biology; Cancer research; Carcinogenesis; Tumor microenvironment; Immune checkpoint; Cancer; Immunology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009678932,0.0001750531,0.001666021,0.0002139564,0.00002526979,0.00001074545,0.0003537759,0.0001254175,0.000173641],"category_scores_gemma":[0.0002417918,0.0001355365,0.0008762681,0.0007094664,0.00008183001,0.00004916427,0.0000680603,0.0005445724,7.769998e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003378007,"about_ca_system_score_gemma":0.001454548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007631928,"about_ca_topic_score_gemma":0.0001655444,"domain_scores_codex":[0.9975116,0.0002884481,0.001366741,0.0001427364,0.0005162007,0.000174337],"domain_scores_gemma":[0.9981566,0.00009884115,0.001248004,0.0001909989,0.0002189063,0.00008666823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003449698,0.00005129073,0.000164546,0.002288188,0.0002737184,0.0002139065,0.0001788641,0.00000321012,0.001679511,5.34896e-7,0.0003538722,0.9913427],"study_design_scores_gemma":[0.001349385,0.0002239223,0.009711542,0.1227506,0.0005117208,0.001744785,0.00009788341,6.716043e-7,0.0006253951,0.000004624892,0.8628627,0.0001167071],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01215341,0.9861499,0.000001615067,0.0007382868,0.0003965177,0.0004248676,0.0000633005,0.000002297374,0.00006981148],"genre_scores_gemma":[0.008920431,0.9905429,0.00004217675,0.000102316,0.0002073383,0.00001193458,0.000001415597,0.00003701195,0.0001344695],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.991226,"threshold_uncertainty_score":0.5527018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01838324469689471,"score_gpt":0.3345164446963467,"score_spread":0.316133199999452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}