{"id":"W3019602056","doi":"10.1634/theoncologist.2020-0194","title":"Successful Treatment of Cytokine Release Syndrome with IL-6 Blockade in a Patient Transitioning from Immune-Checkpoint to MEK/BRAF Inhibition: A Case Report and Review of Literature","year":2020,"lang":"en","type":"review","venue":"The Oncologist","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Cytokine release syndrome; Blockade; Tocilizumab; Melanoma; Immunotherapy; Oncology; Immune checkpoint; Immune system; Adverse effect; Cytokine; Chimeric antigen receptor; Internal medicine; Immunology; Cancer research; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002332693,0.0006646794,0.001326801,0.0021239,0.0003309169,0.0006288661,0.0007884571,0.001080723,0.001279646],"category_scores_gemma":[0.0005994473,0.0002192867,0.0006493249,0.001792984,0.0005462138,0.001036591,0.0003258245,0.001305108,0.0007228884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004065986,"about_ca_system_score_gemma":0.0005743653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006025712,"about_ca_topic_score_gemma":0.001171508,"domain_scores_codex":[0.9998246,0.00002639823,0.00004811298,0.0000411207,0.00004120769,0.00001852769],"domain_scores_gemma":[0.9997115,0.0001616618,0.00005677418,0.00001009155,0.00003254334,0.00002748797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.0001395476,0.0001747776,0.002661534,0.0276296,0.0004199313,0.1017131,0.0003168497,0.000672333,0.00563491,0.002045222,0.0349814,0.8236108],"study_design_scores_gemma":[0.0000527334,0.000226185,0.005913771,0.007198816,0.0006652101,0.60749,0.0004564746,0.000421031,0.002479852,0.001814914,0.3731724,0.0001086512],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001534834,0.9962083,0.0003897615,0.000447063,0.0002986876,0.000008453366,0.00001886907,0.00001235638,0.001081635],"genre_scores_gemma":[0.01209181,0.9855366,0.0004978613,0.0006769053,0.0006045834,0.00001008938,0.000047769,0.000005423537,0.0005288543],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0021239,"threshold_uncertainty_score":0.004280865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03803229358339608,"score_gpt":0.3468623536365209,"score_spread":0.3088300600531249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}