{"id":"W3019624855","doi":"10.1021/acscentsci.0c00313","title":"Defining the Design Parameters for <i>in Vivo</i> Enzyme Delivery Through Protein Spherical Nucleic Acids","year":2020,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Government of Canada; Air Force Research Laboratory; National Cancer Institute; Weizmann Institute of Science; Lefkofsky Family Foundation","keywords":"Nucleic acid; DNA; Intracellular; Oligonucleotide; Linker; Biochemistry; In vitro; Enzyme; In vivo; Chemistry; Cell biology; Biophysics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000265892,0.0001223582,0.0001131636,0.000009550998,0.0001766749,0.00005416327,0.0004030351,0.00006386635,0.000001028234],"category_scores_gemma":[0.0002787807,0.00008324497,0.00006859861,0.0003935221,0.0004257357,0.00001588157,0.0001079448,0.00008070849,0.00000121327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002584276,"about_ca_system_score_gemma":0.000103096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000162268,"about_ca_topic_score_gemma":0.000006118088,"domain_scores_codex":[0.9987413,0.0000462667,0.0001583523,0.0004298733,0.0001730279,0.0004511304],"domain_scores_gemma":[0.9995857,0.00002687498,0.00006274313,0.0001923671,0.0000481514,0.00008413014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006942809,0.00001652226,0.000165906,0.000003207931,0.000005247246,0.000002128926,0.00006836606,0.0002063625,0.9972812,0.0002133033,0.0004926251,0.001475735],"study_design_scores_gemma":[0.0001379387,0.0002339441,0.0000687962,0.000009939528,0.000008671253,0.000003101777,0.00009287419,0.001098933,0.9936976,0.0001750218,0.004337076,0.000136143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8767003,0.0002686485,0.1204499,0.001779875,0.00004225309,0.0005765408,0.00001110322,0.00004718849,0.0001241762],"genre_scores_gemma":[0.8881956,0.00004141983,0.110069,0.001607536,0.0000404219,0.00001821332,0.000003185405,0.000007925845,0.00001671601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01149529,"threshold_uncertainty_score":0.3394631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902073189254292,"score_gpt":0.2619069449892124,"score_spread":0.2428862130966694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}