{"id":"W3019663976","doi":"10.1007/s00702-020-02196-w","title":"The mGlu2/3 antagonist LY-341,495 reverses the anti-dyskinetic and anti-psychotic effects of the mGlu2 activators LY-487,379 and LY-354,740 in the MPTP-lesioned marmoset","year":2020,"lang":"en","type":"article","venue":"Journal of Neural Transmission","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Neurological Institute and Hospital; McGill University","funders":"Weston Brain Institute","keywords":"MPTP; Dyskinesia; Agonist; Antagonist; Pharmacology; Medicine; Psychology; Internal medicine; Dopaminergic; Parkinson's disease; Receptor; Dopamine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008720586,0.0002999128,0.0004147012,0.0001082648,0.001101588,0.0002187778,0.00145181,0.00008978068,0.00001320033],"category_scores_gemma":[0.0007353097,0.0001220102,0.0001894225,0.001106285,0.001066881,0.000355214,0.0001350927,0.001312216,0.000001908819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001466084,"about_ca_system_score_gemma":0.000123331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006138634,"about_ca_topic_score_gemma":7.905647e-7,"domain_scores_codex":[0.9952956,0.002038914,0.0006353368,0.0004680175,0.001041447,0.0005207071],"domain_scores_gemma":[0.995908,0.003048858,0.0004031378,0.0003468836,0.00006230827,0.0002307989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005548272,0.0001265414,0.003142137,0.0001056396,0.000006441479,0.0003115022,0.000662079,0.0000251598,0.9894652,0.00001785924,0.0008324974,0.004750131],"study_design_scores_gemma":[0.002146296,0.001137551,0.1355742,0.0002177428,0.00008197345,0.001005845,0.0002498899,0.00135904,0.8530843,0.0001077228,0.004845184,0.0001903372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608161,0.0005932546,0.00001210681,0.03721397,0.0005893455,0.0007191334,0.000005824028,0.0000104683,0.00003983105],"genre_scores_gemma":[0.9887919,0.00685974,0.000005503401,0.004151969,0.0001125098,0.000005736375,1.003568e-7,0.00002522478,0.00004730616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1363809,"threshold_uncertainty_score":0.8472635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03814075655109114,"score_gpt":0.3155431043843415,"score_spread":0.2774023478332504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}