{"id":"W3019663976","doi":"10.1007/s00702-020-02196-w","title":"The mGlu2/3 antagonist LY-341,495 reverses the anti-dyskinetic and anti-psychotic effects of the mGlu2 activators LY-487,379 and LY-354,740 in the MPTP-lesioned marmoset","year":2020,"lang":"en","type":"article","venue":"Journal of Neural Transmission","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Neurological Institute and Hospital; McGill University","funders":"Weston Brain Institute","keywords":"MPTP; Dyskinesia; Agonist; Antagonist; Pharmacology; Medicine; Psychology; Internal medicine; Dopaminergic; Parkinson's disease; Receptor; Dopamine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086553,0.0003224098,0.0006530502,0.000301093,0.0003109,0.0002808376,0.0003648727,0.0003830153,0.003038887],"category_scores_gemma":[0.0002548727,0.0002245799,0.0001872165,0.000177218,0.0004908848,0.000293529,0.0001993317,0.001049503,0.0007067446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003113888,"about_ca_system_score_gemma":0.000538072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002806764,"about_ca_topic_score_gemma":0.005951236,"domain_scores_codex":[0.9998974,0.00001646951,0.000008869346,0.00000863589,0.00002338103,0.00004535926],"domain_scores_gemma":[0.999895,0.00001401654,0.00002230509,0.000009629746,0.000007977541,0.0000510742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001476364,0.0001405441,0.0002798688,0.00006181654,0.00003234949,0.0002410987,0.00007282845,0.0001407062,0.9925378,0.0002367935,0.0002497608,0.004530049],"study_design_scores_gemma":[0.0005252609,0.005042245,0.01837142,0.00001948893,0.00009601749,0.001239737,0.0002199265,0.002386267,0.9691236,0.0003450127,0.002592082,0.00003888295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975359,0.0003306636,0.0002254418,0.000103411,0.0000158066,0.00001705886,0.0001753647,0.00008160936,0.00151461],"genre_scores_gemma":[0.9967829,0.000396129,0.0005303327,0.00007022994,0.00001113445,0.00002263586,0.0003479327,0.00001819082,0.001820477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003038887,"threshold_uncertainty_score":0.01016605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03814075655109114,"score_gpt":0.3155431043843415,"score_spread":0.2774023478332504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}