{"id":"W3019787711","doi":"10.3390/ijms21093047","title":"The Serine Protease Autotransporters TagB, TagC, and Sha from Extraintestinal Pathogenic Escherichia coli Are Internalized by Human Bladder Epithelial Cells and Cause Actin Cytoskeletal Disruption","year":2020,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Enterobacteriaceae and Cronobacter Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Cegep de Saint Hyacinthe","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Serine protease; Biology; Secretion; Internalization; Mucin; Microbiology; Proteases; Serine; Epithelium; Cell biology; Protease; Cell; Biochemistry; Phosphorylation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287326,0.0001958033,0.0001510346,0.0001194218,0.00009192155,0.0001694757,0.00009523067,0.0002240134,0.0006962828],"category_scores_gemma":[0.0001116589,0.0000973085,0.000180591,0.0001179399,0.0001285042,0.00009656935,0.0001531394,0.0003172074,0.0001714453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747987,"about_ca_system_score_gemma":0.0001744633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009032902,"about_ca_topic_score_gemma":0.001063503,"domain_scores_codex":[0.9998711,0.00002611216,0.00001212514,0.00001845116,0.00003899237,0.00003311156],"domain_scores_gemma":[0.9999179,0.00001505808,0.00002200343,0.00001419294,0.00001013832,0.0000206897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007050786,0.00001546874,0.0002561251,0.00001413712,0.000002502127,0.00003747331,0.000008600566,0.00001667276,0.9989586,0.00002655411,0.00001299888,0.0005803962],"study_design_scores_gemma":[0.000008040458,0.0002561304,0.007204005,0.000002515631,0.000005890794,0.0004132691,0.00003288436,0.0003829102,0.9909464,0.00001671692,0.0007290332,0.00000208282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977958,0.0005299697,0.001095772,0.00005063135,0.00000930924,0.00001568176,0.0001275881,0.00002159035,0.000353613],"genre_scores_gemma":[0.9962507,0.0002903417,0.001622393,0.00003947542,0.000002329564,0.00001841561,0.0003923007,0.000007462977,0.001376565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009032902,"threshold_uncertainty_score":0.00232929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617062819692019,"score_gpt":0.2850459703402191,"score_spread":0.2688753421432989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}