{"id":"W3019822976","doi":"10.1016/j.celrep.2020.107522","title":"Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"Deutsche Forschungsgemeinschaft; European Hematology Association; Deutsche Krebshilfe; BMC Software","keywords":"Follicular lymphoma; Tumor microenvironment; Immune system; Lymphoma; Cancer research; Immunology; Cathepsin; Follicular phase; Biology; Medicine; Enzyme; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009276823,0.0002537724,0.00012502,0.0003559284,0.0001490707,0.0003020465,0.00007596269,0.0001898942,0.001785707],"category_scores_gemma":[0.0001028454,0.00009367208,0.0002139995,0.0001638497,0.0003708583,0.0001434555,0.0001737511,0.0002458371,0.0001867996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000350292,"about_ca_system_score_gemma":0.0001624772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015798,"about_ca_topic_score_gemma":0.001035295,"domain_scores_codex":[0.9999163,0.00001868256,0.000008022206,0.00001475388,0.00001679863,0.00002546157],"domain_scores_gemma":[0.9999346,0.000007971544,0.00002470318,0.000008347035,0.000005342774,0.00001906358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003398715,0.00002846655,0.002019438,0.00003752364,0.0000118196,0.0004780314,0.00002948344,0.00008768122,0.9948434,0.0001322496,0.00006479485,0.001927186],"study_design_scores_gemma":[0.0001389822,0.001178741,0.06351449,0.0000131319,0.00006314015,0.006162995,0.0002675008,0.001045124,0.9226843,0.0002672886,0.004650691,0.00001354432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980369,0.0006404385,0.0003122723,0.0000383406,0.000006260441,0.000008572315,0.000107089,0.00002877083,0.0008213228],"genre_scores_gemma":[0.9993737,0.0001156306,0.00007568672,0.00001000556,0.00000244197,0.000004134951,0.00007395742,0.000002494392,0.0003420374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001785707,"threshold_uncertainty_score":0.005973756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068212978942895,"score_gpt":0.2098067202500031,"score_spread":0.1991245904605742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}