{"id":"W3019927786","doi":"10.1093/neuonc/nou206.58","title":"EPIGENOME ALTERATIONS DEFINE LETHAL CIMP POSITIVE EPENDYMOMAS OF INFANCY","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Epigenetics; Biology; Epigenome; Atypical teratoid rhabdoid tumor; DNA methylation; CpG site; Genetics; Cancer research; Exome sequencing; Mutation; Medulloblastoma; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510248,0.0001419732,0.0002279924,0.00006838148,0.00007736598,0.000008936547,0.0001506175,0.0002170648,0.00003914422],"category_scores_gemma":[0.0003062041,0.0001452317,0.00009145114,0.00009088013,0.0001007389,0.000003940301,0.000103747,0.0001212666,0.00001903458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001175004,"about_ca_system_score_gemma":0.0001212067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003110339,"about_ca_topic_score_gemma":0.00008237631,"domain_scores_codex":[0.9987545,0.000262402,0.0003303829,0.0003224007,0.0001039636,0.0002263666],"domain_scores_gemma":[0.9991309,0.0001241954,0.0001801247,0.0003214924,0.0001548006,0.00008848341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005299691,0.00009695472,0.003574282,0.000007268082,0.00002127699,0.00000508015,0.0001008968,0.0001794762,0.9856957,0.001688893,0.000124645,0.008452483],"study_design_scores_gemma":[0.0007147887,0.002008429,0.01174572,0.000003926638,0.00002857744,0.0000146007,0.000014893,0.0001251923,0.840322,0.0006887647,0.1441697,0.0001633669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635637,0.0005346262,0.01010991,0.0005674009,0.0003544872,0.0002022837,0.00003401894,0.00001086567,0.02462269],"genre_scores_gemma":[0.9970745,0.0001698524,0.001712795,0.0004235251,0.0003220663,0.00002094659,0.0001774124,0.00002303144,0.00007587264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1453737,"threshold_uncertainty_score":0.5922376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215495661759549,"score_gpt":0.2810068465490747,"score_spread":0.2688518899314792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}