{"id":"W3019962442","doi":"10.1016/j.eururo.2020.03.019","title":"Effect of Enzalutamide plus Androgen Deprivation Therapy on Health-related Quality of Life in Patients with Metastatic Hormone-sensitive Prostate Cancer: An Analysis of the ARCHES Randomised, Placebo-controlled, Phase 3 Study","year":2020,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Astellas Foundation for Research on Metabolic Disorders; Astellas Pharma; Pfizer","keywords":"Medicine; Enzalutamide; Placebo; Prostate cancer; Androgen deprivation therapy; Quality of life (healthcare); Internal medicine; Visual analogue scale; Oncology; Urology; Cancer; Physical therapy; Androgen receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003743178,0.001038394,0.00324661,0.0004202852,0.0002857638,0.00089732,0.0006907706,0.0009430957,0.003256276],"category_scores_gemma":[0.002373196,0.0004107142,0.004026922,0.0004996012,0.0009451952,0.0006814321,0.0003507815,0.001575449,0.0003098616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000811492,"about_ca_system_score_gemma":0.00116776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088373,"about_ca_topic_score_gemma":0.003027225,"domain_scores_codex":[0.9979849,0.001410152,0.0001363199,0.0001997158,0.0001627002,0.0001061636],"domain_scores_gemma":[0.9985777,0.0004900787,0.0004238476,0.0001112215,0.00009521798,0.000301832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9735876,0.002601213,0.001428543,0.0008341584,0.003669499,0.00003445351,0.00003640557,0.0003299222,0.001858646,0.00004274837,0.0002606153,0.01531627],"study_design_scores_gemma":[0.8949423,0.09119748,0.01016887,0.00006667023,0.002356217,0.00003800451,0.00002217001,0.000349452,0.0002571817,0.0000890724,0.0004927953,0.00001963579],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794844,0.01578295,0.0005146908,0.0003619783,0.0002111332,0.001586365,0.0008716637,0.00005931531,0.001127599],"genre_scores_gemma":[0.99192,0.004150046,0.0008521865,0.0004269301,0.0001978794,0.001131382,0.0006452028,0.00001174137,0.0006647072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003743178,"threshold_uncertainty_score":0.01979601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0378007804806476,"score_gpt":0.3445056307249567,"score_spread":0.306704850244309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}