{"id":"W3020013968","doi":"10.1002/cbic.202000142","title":"Role of Two Exceptional <i>trans</i> Adenylation Domains and MbtH‐like Proteins in the Biosynthesis of the Nonribosomal Peptide WS9324A from <i>Streptomyces calvus</i> ATCC 13382","year":2020,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Deutsche Forschungsgemeinschaft","keywords":"Adenylylation; Nonribosomal peptide; Biosynthesis; Biology; Amino acid; Gene cluster; Peptide; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009865165,0.0003108354,0.0001659713,0.0001045983,0.0001077866,0.0002653325,0.0001099526,0.0002068283,0.0005462468],"category_scores_gemma":[0.0001317192,0.0001038812,0.0002200476,0.0001106397,0.0002371647,0.0001737027,0.0002411686,0.0003091254,0.00026251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780856,"about_ca_system_score_gemma":0.0001777833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004071605,"about_ca_topic_score_gemma":0.0003515715,"domain_scores_codex":[0.9999033,0.000020745,0.000009908203,0.00002454498,0.00001947814,0.00002200899],"domain_scores_gemma":[0.9998243,0.00002501828,0.00006007873,0.00002263065,0.000008387608,0.00005959727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000114262,0.000008389071,0.0005338104,0.00001521671,0.000002447331,0.00007686437,0.000009588372,0.00006155321,0.9984418,0.00009711213,0.000005376675,0.0006335468],"study_design_scores_gemma":[0.000006770966,0.0001374896,0.008353237,0.000002727673,0.00000925003,0.0005189935,0.00003113343,0.0006216849,0.9894338,0.00006608534,0.0008134618,0.00000548318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971094,0.0002964919,0.001847118,0.00002619701,0.000006735036,0.000005980943,0.0001099252,0.0000272251,0.0005710458],"genre_scores_gemma":[0.9981882,0.00004853223,0.001197377,0.000007409507,0.000001690059,0.000003216075,0.0002046678,0.000006057478,0.0003428512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005462468,"threshold_uncertainty_score":0.001827359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01044729396974493,"score_gpt":0.2174322367548493,"score_spread":0.2069849427851044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}