{"id":"W3020013968","doi":"10.1002/cbic.202000142","title":"Role of Two Exceptional <i>trans</i> Adenylation Domains and MbtH‐like Proteins in the Biosynthesis of the Nonribosomal Peptide WS9324A from <i>Streptomyces calvus</i> ATCC 13382","year":2020,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Deutsche Forschungsgemeinschaft","keywords":"Adenylylation; Nonribosomal peptide; Biosynthesis; Biology; Amino acid; Gene cluster; Peptide; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958966,0.0002052484,0.0003677135,0.00003491705,0.00007097235,0.0000155041,0.0002601382,0.0001285401,0.0001290453],"category_scores_gemma":[0.0001259806,0.0001193439,0.0001653164,0.0003594506,0.0002754477,0.0000714445,0.00006383806,0.0002545552,0.000003114624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002273378,"about_ca_system_score_gemma":0.00008608289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003043668,"about_ca_topic_score_gemma":0.00009698723,"domain_scores_codex":[0.998579,0.00007860067,0.0004143031,0.0003768122,0.0003548849,0.0001964265],"domain_scores_gemma":[0.9991568,0.0001410624,0.000197483,0.0003430794,0.00008795962,0.00007364481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001879722,0.0001369643,0.006212951,0.0001289654,0.00005037765,0.000001841624,0.001546959,0.000001152622,0.9903004,0.00004814083,0.0004094009,0.0009748814],"study_design_scores_gemma":[0.0008786723,0.00007301736,0.02295214,0.0001868598,0.0001273946,0.000009414816,0.0005405589,0.00003492326,0.9731665,0.0001112555,0.001790872,0.000128381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877095,0.0008661644,0.000008658958,0.0100623,0.00003209745,0.0006524388,0.0001760498,0.00001703048,0.0004757702],"genre_scores_gemma":[0.9979537,0.00007906347,0.0007025927,0.0008607571,0.0002929985,0.000005312334,0.00004497626,0.00001761654,0.00004295473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01713388,"threshold_uncertainty_score":0.4866705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01044729396974493,"score_gpt":0.2174322367548493,"score_spread":0.2069849427851044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}