{"id":"W3020276271","doi":"10.1002/ana.25757","title":"Randomized Clinical Trial of<scp>First‐Line</scp>Genome Sequencing in Pediatric White Matter Disorders","year":2020,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre; Montreal Children's Hospital","funders":"National Health and Medical Research Council; National Institute of Neurological Disorders and Stroke; Medical Research Council; Canadian Institutes of Health Research; Children's Hospital of Philadelphia; Hope Foundation; Illumina; Pennsylvania Department of Health; Hunter's Hope Foundation","keywords":"Randomized controlled trial; White matter; Medicine; Whole genome sequencing; Genetics; Genome; Biology; Internal medicine; Gene; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002462219,0.001191672,0.002024416,0.000343044,0.0003870396,0.0007909928,0.0007220192,0.001609256,0.006420968],"category_scores_gemma":[0.002549174,0.0003963643,0.001093739,0.0002812401,0.001032411,0.0006834795,0.0004128105,0.002405201,0.0006827885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008093085,"about_ca_system_score_gemma":0.001438565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007355122,"about_ca_topic_score_gemma":0.001464771,"domain_scores_codex":[0.9988381,0.0006705993,0.00006442245,0.0002042552,0.00008105222,0.0001415882],"domain_scores_gemma":[0.9974493,0.0007506839,0.0007138196,0.0002285646,0.0001438693,0.0007137791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9841105,0.005163047,0.0008237914,0.0001579593,0.0003288251,0.00002879257,0.000021039,0.0002013248,0.0007639608,0.0001073264,0.0004714728,0.007821999],"study_design_scores_gemma":[0.8792096,0.1172949,0.001912619,0.00002389543,0.0002045288,0.00004421183,0.00001178762,0.0003402113,0.000345655,0.0001395367,0.0004647889,0.000008365056],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932059,0.001605041,0.0003778442,0.0005694877,0.0004214815,0.002348485,0.0003734918,0.00005846455,0.001039823],"genre_scores_gemma":[0.9926018,0.0007826687,0.001139276,0.0006583828,0.0003913767,0.002847344,0.0004538233,0.000008118498,0.001117209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006420968,"threshold_uncertainty_score":0.02148026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05542181311713937,"score_gpt":0.3279416825215845,"score_spread":0.2725198694044451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}