{"id":"W3020276271","doi":"10.1002/ana.25757","title":"Randomized Clinical Trial of<scp>First‐Line</scp>Genome Sequencing in Pediatric White Matter Disorders","year":2020,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre; Montreal Children's Hospital","funders":"National Health and Medical Research Council; National Institute of Neurological Disorders and Stroke; Medical Research Council; Canadian Institutes of Health Research; Children's Hospital of Philadelphia; Hope Foundation; Illumina; Pennsylvania Department of Health; Hunter's Hope Foundation","keywords":"Randomized controlled trial; White matter; Medicine; Whole genome sequencing; Genetics; Genome; Biology; Internal medicine; Gene; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005697771,0.0001247436,0.0004851299,0.00007294997,0.00001457926,0.000004089743,0.0001745031,0.0001882788,0.00002516827],"category_scores_gemma":[0.001280034,0.000116517,0.0003267696,0.0001334509,0.0001475563,0.00000425395,0.00008723771,0.00011313,0.00001280297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":8.654625e-7,"about_ca_system_score_gemma":0.00009048349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007172251,"about_ca_topic_score_gemma":0.00001098274,"domain_scores_codex":[0.9980965,0.0005530078,0.0007338991,0.0003233782,0.00009724698,0.0001959625],"domain_scores_gemma":[0.9990914,0.0002128948,0.0002985077,0.0002115317,0.00006291309,0.000122745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5280532,0.0005489138,0.4480102,0.0002108549,0.0001618574,0.00002637248,0.000271159,0.007838304,0.006357838,0.0001134418,0.007916299,0.0004914903],"study_design_scores_gemma":[0.7650059,0.004513064,0.2118816,0.000004842699,0.0001472258,0.000005616912,0.00003133325,0.001862118,0.001235865,0.001041122,0.01401982,0.0002515519],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921405,0.0003560132,0.0002850131,0.005729924,0.0001418232,0.0003715508,0.00001159626,0.000005822561,0.0009576989],"genre_scores_gemma":[0.9910912,0.001432867,0.00003035694,0.006984012,0.0003426248,0.00001552475,0.00003627978,0.0000154132,0.00005172718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2369526,"threshold_uncertainty_score":0.4751427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05542181311713937,"score_gpt":0.3279416825215845,"score_spread":0.2725198694044451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}