{"id":"W3020413154","doi":"10.1038/s41598-020-64093-2","title":"Chitinase 3-like 1 is neurotoxic in primary cultured neurons","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Studies on Chitinases and Chitosanases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Agència de Gestió d'Ajuts Universitaris i de Recerca; Red Española de Esclerosis Múltiple; Ministerio de Ciencia e Innovación; Generalitat de Catalunya","keywords":"Neurite; Chitinase; Multiple sclerosis; In vitro; Biology; Neuron; Immunofluorescence; Central nervous system; Biomarker; Cytotoxic T cell; Neurotoxicity; Immune system; Cell biology; Recombinant DNA; Immunology; Neuroscience; Medicine; Toxicity; Enzyme; Antibody; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200517,0.000422408,0.0003402082,0.0002213579,0.0002281897,0.0002996363,0.0001878406,0.0003921062,0.001425358],"category_scores_gemma":[0.0001606356,0.0001421288,0.0004012224,0.0002515981,0.0002129779,0.0001656905,0.0001968077,0.0007749426,0.0004502469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003566152,"about_ca_system_score_gemma":0.0003356724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003049318,"about_ca_topic_score_gemma":0.004714016,"domain_scores_codex":[0.9998094,0.00002303488,0.00002049527,0.00003918208,0.00005843772,0.00004944423],"domain_scores_gemma":[0.9998283,0.00004660598,0.00002486888,0.00002326181,0.00004029325,0.00003652289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007211554,0.0000154568,0.0001335668,0.00005994826,0.000007777946,0.0001045711,0.00001900511,0.00001687172,0.9990908,0.00001311377,0.00002510642,0.000441811],"study_design_scores_gemma":[0.00001201537,0.0005087527,0.008585308,0.00001615672,0.00002893362,0.0004550721,0.00009129648,0.0002272205,0.9889795,0.0000423169,0.001049361,0.000004230058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841585,0.007552629,0.003037746,0.0001830046,0.0001216644,0.00005680936,0.001024742,0.0000685272,0.003796359],"genre_scores_gemma":[0.9838222,0.004101154,0.003377809,0.0001725702,0.00002681826,0.0001281415,0.001679552,0.00002398664,0.006667744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003049318,"threshold_uncertainty_score":0.006063104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315164898446094,"score_gpt":0.2342177708562574,"score_spread":0.2210661218717964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}