{"id":"W3020430037","doi":"10.1016/j.chom.2020.04.001","title":"Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes","year":2020,"lang":"en","type":"letter","venue":"Cell Host & Microbe","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Lytic cycle; Biology; CRISPR; Cas9; Lysogenic cycle; Listeria; Prophage; Bacteriophage; Genome; Microbiology; Listeria monocytogenes; Genetics; Bacteria; Virus; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002828313,0.0005765697,0.0005592062,0.0004531084,0.001536435,0.002548181,0.000686736,0.0174381,0.004312265],"category_scores_gemma":[0.007615698,0.0005328229,0.0007745802,0.000136961,0.001591867,0.0009070665,0.001043028,0.01409309,0.003390939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002815136,"about_ca_system_score_gemma":0.001354061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00284095,"about_ca_topic_score_gemma":0.005814761,"domain_scores_codex":[0.9984799,0.0002999829,0.0001032667,0.000148392,0.0006639743,0.0003044908],"domain_scores_gemma":[0.9960247,0.002322682,0.000219108,0.000200646,0.0007060342,0.0005268133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005270395,0.0001484363,0.0008696205,0.00008900656,0.00005657191,0.001646405,0.0001078233,0.0001866178,0.01059872,0.006010691,0.9454897,0.03426939],"study_design_scores_gemma":[0.0005470432,0.0003799145,0.002692391,0.000107802,0.0000623199,0.00149315,0.0001983134,0.001569088,0.02073929,0.01074023,0.9613805,0.00009000361],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.006834705,0.005954001,0.002386246,0.8944991,0.06526027,0.00008596637,0.0002165599,0.0004078222,0.0243553],"genre_scores_gemma":[0.05806835,0.003293841,0.001742617,0.8262085,0.02672742,0.0001536868,0.000185893,0.0001264244,0.08349324],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0174381,"threshold_uncertainty_score":0.02042538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01096625115746664,"score_gpt":0.2611662163160983,"score_spread":0.2501999651586317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}