{"id":"W3020430037","doi":"10.1016/j.chom.2020.04.001","title":"Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes","year":2020,"lang":"en","type":"letter","venue":"Cell Host & Microbe","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Lytic cycle; Biology; CRISPR; Cas9; Lysogenic cycle; Listeria; Prophage; Bacteriophage; Genome; Microbiology; Listeria monocytogenes; Genetics; Bacteria; Virus; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00005530204,0.000422099,0.0003000183,0.00008215337,0.00007352804,0.00008047099,0.0004156814,0.0005710517,0.00007117081],"category_scores_gemma":[0.00002298527,0.000454498,0.0001780118,0.0001290759,0.00002958311,0.000002312918,0.0002774357,0.0005095041,0.000173651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003697635,"about_ca_system_score_gemma":0.00009791679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002367387,"about_ca_topic_score_gemma":0.00001033339,"domain_scores_codex":[0.9983913,0.00004840804,0.00028169,0.0007321598,0.0001252822,0.0004211462],"domain_scores_gemma":[0.9991797,0.000008023921,0.00009742154,0.0005439113,0.00006382265,0.0001070967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000871877,0.000006823846,0.000006170595,0.0001408713,0.00003128726,0.00003854126,0.00005762713,0.00001082509,0.624005,4.45331e-8,0.3751232,0.000570868],"study_design_scores_gemma":[0.0001161338,0.0001003245,0.00001872698,0.0000160754,0.00003209059,0.0000177834,0.000009680151,0.000001868082,0.4855902,6.645434e-7,0.5138126,0.0002839178],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5486096,0.04749121,0.02974993,0.3568476,0.004569132,0.006812271,0.001427923,0.0003695325,0.004122831],"genre_scores_gemma":[0.1849073,0.001687138,0.01011547,0.7306559,0.01773868,0.0005206724,0.0100452,0.0007601344,0.04356949],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.3738083,"threshold_uncertainty_score":0.9997907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01096625115746664,"score_gpt":0.2611662163160983,"score_spread":0.2501999651586317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}