{"id":"W3020482066","doi":"10.1016/s1470-2045(20)30112-1","title":"Abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus standard-of-care chemotherapy in women with hormone receptor-positive, HER2-positive advanced breast cancer (monarcHER): a randomised, open-label, phase 2 trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":261,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Eisai; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Trastuzumab; Fulvestrant; Internal medicine; Breast cancer; Oncology; Metastatic breast cancer; Cancer; Chemotherapy; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005428988,0.0007474941,0.003510928,0.000114869,0.0001809517,0.00004691131,0.0006968445,0.0002405826,0.0004747813],"category_scores_gemma":[0.00005384568,0.0004461976,0.00008638174,0.0009333872,0.001033806,0.0003433683,0.0001165535,0.001009205,0.000006258132],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003914137,"about_ca_system_score_gemma":0.00413163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002072303,"about_ca_topic_score_gemma":0.0006096729,"domain_scores_codex":[0.9957322,0.000600987,0.0008247943,0.0009859314,0.0007050584,0.001151022],"domain_scores_gemma":[0.9972798,0.0006044228,0.0006610068,0.0006129689,0.0004130065,0.0004288199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8245567,0.0008862953,0.00003322951,0.0001702537,0.001142556,0.0002907111,0.03222229,0.0003566729,0.006510944,0.00002675874,0.00007793835,0.1337256],"study_design_scores_gemma":[0.8765252,0.09846667,0.0005172402,0.0006340889,0.0003476645,0.0002977377,0.01478693,0.0001879633,0.002551254,0.00001541097,0.005072714,0.0005970846],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714132,0.002106033,0.001199873,0.01428448,0.0001908588,0.008647365,0.001182818,0.000142461,0.000832907],"genre_scores_gemma":[0.9861772,0.001556678,0.005922321,0.002477188,0.0008035535,0.002700649,0.00008627267,0.0001877813,0.00008836341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1331286,"threshold_uncertainty_score":0.9999096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05342743091466359,"score_gpt":0.3829554564653619,"score_spread":0.3295280255506983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}