{"id":"W3020538763","doi":"10.1038/s41593-020-0621-y","title":"Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons","year":2020,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":541,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada's Michael Smith Genome Sciences Centre; Centre for Addiction and Mental Health; McGill University and Génome Québec Innovation Centre; University of British Columbia; McGill University; Douglas Mental Health University Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; Canada First Research Excellence Fund; Government of Canada; National Alliance for Research on Schizophrenia and Depression","keywords":"Neuroscience; Transcriptome; Dorsolateral prefrontal cortex; Prefrontal cortex; Excitatory postsynaptic potential; Biology; Oligodendrocyte; Major depressive disorder; Psychology; Gene expression; Central nervous system; Myelin; Gene; Amygdala; Genetics; Inhibitory postsynaptic potential; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004205808,0.0001771046,0.0001610901,0.00002573313,0.00008757063,0.00002965926,0.0005004425,0.0002001043,0.000001277588],"category_scores_gemma":[0.00009111605,0.0001413759,0.00008037897,0.0002078877,0.0003457539,0.00001374179,0.0001166525,0.0003733588,3.645816e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007170068,"about_ca_system_score_gemma":0.00005556053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001628113,"about_ca_topic_score_gemma":0.00009319681,"domain_scores_codex":[0.9987679,0.00006233411,0.000206949,0.0005421652,0.0001697574,0.0002508957],"domain_scores_gemma":[0.9995058,0.00001891033,0.00009024195,0.0002492723,0.00003370349,0.0001020679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000971327,0.00008231679,0.006515651,0.00002799531,0.000002472615,0.000002564548,0.0001869096,0.00006127498,0.9924755,0.00002247066,0.00007254116,0.0004532479],"study_design_scores_gemma":[0.0007269834,0.0002870417,0.07616902,0.00001293208,0.0000166454,0.00001246637,0.00003020987,0.000772035,0.915662,0.00001676343,0.00612113,0.0001727529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973702,0.001004466,0.0002886211,0.0003660689,0.0004260582,0.0002973542,0.00009291281,0.00001120093,0.0001430591],"genre_scores_gemma":[0.997645,0.0001540228,0.00009759681,0.00198957,0.00004487949,0.000008210294,0.000003766493,0.00002243365,0.00003457362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07681341,"threshold_uncertainty_score":0.5765144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009953891183489074,"score_gpt":0.2177575974643761,"score_spread":0.2078037062808871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}