{"id":"W3020556534","doi":"10.1101/741777","title":"Inflammation in Alzheimer’s disease: do sex and APOE matter?","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Women's Health Research Institute; University of British Columbia","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Health Canada; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Government of Canada; Northern California Institute for Research and Education; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Inflammation; Allele; Neuropathology; Internal medicine; Genotype; Disease; Endocrinology; Neuroinflammation; Medicine; Psychology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001368411,0.000371794,0.000513542,0.0005696312,0.0002608183,0.000966031,0.0002910458,0.0006052378,0.003657639],"category_scores_gemma":[0.002839185,0.0001628011,0.0007527368,0.000958075,0.0003798599,0.0007175499,0.0002994427,0.0003875437,0.0003827494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001178185,"about_ca_system_score_gemma":0.0002280581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001629584,"about_ca_topic_score_gemma":0.002353456,"domain_scores_codex":[0.9994529,0.0002593488,0.00004892666,0.0001061782,0.00007173314,0.00006094117],"domain_scores_gemma":[0.998482,0.0006430783,0.0004566057,0.0001152985,0.0001277837,0.0001751735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002059184,0.00008903486,0.9809054,0.0001011792,0.0003851465,0.0001885274,0.0002378011,0.00004614383,0.0006842302,0.0001106662,0.0003640974,0.01482853],"study_design_scores_gemma":[0.00001846274,0.0003549634,0.997512,0.00005397033,0.0001993366,0.000328331,0.0002898384,0.0001485177,0.0001106605,0.0003213124,0.0006561396,0.000006568783],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769222,0.01951926,0.0003496407,0.0008715314,0.000121925,0.00001274541,0.0007368426,0.000006133016,0.001459772],"genre_scores_gemma":[0.995796,0.002870493,0.000162067,0.0001993181,0.0001291517,0.000007543802,0.0002559148,0.000004881619,0.0005747047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003657639,"threshold_uncertainty_score":0.012236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02060216814862488,"score_gpt":0.2311412948352088,"score_spread":0.2105391266865839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}