{"id":"W3020556534","doi":"10.1101/741777","title":"Inflammation in Alzheimer’s disease: do sex and APOE matter?","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Women's Health Research Institute; University of British Columbia","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Health Canada; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Government of Canada; Northern California Institute for Research and Education; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Inflammation; Allele; Neuropathology; Internal medicine; Genotype; Disease; Endocrinology; Neuroinflammation; Medicine; Psychology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004052705,0.0004329762,0.0004350288,0.0003134776,0.0001101587,0.0004306414,0.000435586,0.0002973832,0.000192049],"category_scores_gemma":[0.0001698301,0.0004665041,0.0000847847,0.0003050175,0.0001060874,0.0002536736,0.00057386,0.0006535829,0.0004157166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001082672,"about_ca_system_score_gemma":0.000193732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002271641,"about_ca_topic_score_gemma":5.177317e-7,"domain_scores_codex":[0.9973363,0.0002216536,0.0004672213,0.001129104,0.0003875837,0.0004581325],"domain_scores_gemma":[0.9984195,0.0001023749,0.000295745,0.0008567825,0.00006725126,0.0002584072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004155806,0.00005718051,0.04273616,0.0002864779,0.00001973284,0.00005689405,0.00002852284,0.0003209584,0.9553518,0.0008906815,0.0001920248,0.00001797556],"study_design_scores_gemma":[0.0009700455,0.00003872132,0.2006602,0.001077424,0.0001352031,3.103335e-8,0.00000481174,0.004672077,0.7759982,0.00002739446,0.01477632,0.001639585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967067,0.0009842657,0.00009818103,0.0002812075,0.0008329186,0.000794213,0.00008226096,0.0001756531,0.00004456558],"genre_scores_gemma":[0.9987314,0.000264517,0.0002600672,0.000278127,0.0002669926,0.00006897001,1.469717e-7,0.0001188179,0.00001100114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1793537,"threshold_uncertainty_score":0.9997787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02060216814862488,"score_gpt":0.2311412948352088,"score_spread":0.2105391266865839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}