{"id":"W3020654673","doi":"10.1093/jnci/djaa054","title":"Impact of Stopping Trastuzumab in Early Breast Cancer: A Population-Based Study in Ontario, Canada","year":2020,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Queen's University; McMaster University; Ottawa Hospital; University of Ottawa","funders":"Ontario Ministry of Health and Long-Term Care","keywords":"Medicine; Trastuzumab; Hazard ratio; Internal medicine; Breast cancer; Cardiotoxicity; Discontinuation; Population; Confidence interval; Retrospective cohort study; Cancer; Oncology; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008729908,0.0004810455,0.0006502387,0.0008360322,0.002453159,0.001211195,0.001481212,0.0005875377,0.001535049],"category_scores_gemma":[0.002506061,0.0004813971,0.0008297146,0.003933724,0.0010207,0.0003880093,0.000818731,0.0007440549,0.00016654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.03503859,"about_ca_system_score_gemma":0.03810904,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9906708,"about_ca_topic_score_gemma":0.9929166,"domain_scores_codex":[0.9984093,0.0001332753,0.0001110734,0.0002876165,0.0005338208,0.0005250097],"domain_scores_gemma":[0.996684,0.0002034622,0.0009721626,0.0001378777,0.001205496,0.0007970402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000106856,0.00002565605,0.9974753,0.00002789878,0.00006927102,0.00009015459,0.0002965905,0.00006004296,0.0001123204,0.0000371217,0.0004944768,0.001204315],"study_design_scores_gemma":[0.00002381458,0.00003528439,0.9986149,0.00002222728,0.00004805702,0.00006741016,0.00045833,0.0001632024,0.00002295644,0.00001645212,0.0005187241,0.000008593188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941035,0.0009583535,0.00009231574,0.0004150181,0.00001378791,0.00007087334,0.002805217,0.000008338087,0.00153276],"genre_scores_gemma":[0.9979514,0.0004684408,0.00006982614,0.0001502094,0.000007948091,0.00001982899,0.0008365926,0.000004239139,0.0004914422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03503859,"threshold_uncertainty_score":0.2542239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09539194288725586,"score_gpt":0.3989825000861661,"score_spread":0.3035905571989103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}