{"id":"W3020654673","doi":"10.1093/jnci/djaa054","title":"Impact of Stopping Trastuzumab in Early Breast Cancer: A Population-Based Study in Ontario, Canada","year":2020,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Queen's University; McMaster University; Ottawa Hospital; University of Ottawa","funders":"Ontario Ministry of Health and Long-Term Care","keywords":"Medicine; Trastuzumab; Hazard ratio; Internal medicine; Breast cancer; Cardiotoxicity; Discontinuation; Population; Confidence interval; Retrospective cohort study; Cancer; Oncology; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004541651,0.0001416372,0.0004354091,0.0002512764,0.00004792806,0.00001557476,0.000315155,0.00004859992,0.0002707728],"category_scores_gemma":[0.000249277,0.0001013157,0.0001493242,0.0008038729,0.00003688201,0.0001968489,0.00003528517,0.0008150765,2.837286e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.01447635,"about_ca_system_score_gemma":0.0356511,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9866117,"about_ca_topic_score_gemma":0.9950032,"domain_scores_codex":[0.9969872,0.00009332129,0.0007424,0.0001598734,0.001791826,0.0002253709],"domain_scores_gemma":[0.998571,0.00006968493,0.0003911102,0.00009710422,0.0007003648,0.0001707687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009180155,0.0001728607,0.9006889,0.00003865971,0.0001187856,0.0000520761,0.0008177491,0.09558749,0.0002401078,0.000005732256,0.0007149216,0.0006446706],"study_design_scores_gemma":[0.00351873,0.0002805286,0.9944702,0.0004742907,0.0000348173,0.00002433975,0.00005767729,0.0007155152,0.00004897485,0.00001345747,0.0002752249,0.00008626907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932808,0.0001367667,0.00000488642,0.005394964,0.0004749297,0.0004715824,0.0001250521,0.000002463867,0.0001085104],"genre_scores_gemma":[0.9989673,0.000008494246,0.00003706364,0.0005743416,0.0003421069,0.00002385821,0.000002947375,0.00001369103,0.00003018356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09487198,"threshold_uncertainty_score":0.9893069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09539194288725586,"score_gpt":0.3989825000861661,"score_spread":0.3035905571989103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}