{"id":"W3020695284","doi":"10.1016/j.cell.2020.04.004","title":"Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2262,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Toronto; St. Michael's Hospital; Stemcell Technologies","funders":"H2020 Marie Skłodowska-Curie Actions; European Research Council; Canadian Institutes of Health Research; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Cáncer; Fundación Científica Asociación Española Contra el Cáncer","keywords":"Biology; Vero cell; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Angiotensin-converting enzyme 2; Coronavirus; Recombinant DNA; Receptor; Coronavirus disease 2019 (COVID-19); Lung; Organoid; Betacoronavirus; HEK 293 cells; 2019-20 coronavirus outbreak; Virus; Immunology; Gene; Cell biology; Internal medicine; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003746131,0.0004023791,0.0002522572,0.000139555,0.0001385373,0.0003637506,0.0001750293,0.0002279116,0.001989843],"category_scores_gemma":[0.0001331535,0.00009571519,0.0002898241,0.0001321007,0.0002022835,0.0002007299,0.0001379602,0.0007653889,0.0006038346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001934406,"about_ca_system_score_gemma":0.0002857333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005957207,"about_ca_topic_score_gemma":0.001086163,"domain_scores_codex":[0.9997546,0.00005252603,0.00002037833,0.00004015368,0.00006035927,0.00007204773],"domain_scores_gemma":[0.9999251,0.00002075481,0.00001136983,0.00001147757,0.00001037499,0.00002091292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004369049,0.0002361185,0.0001386943,0.0000614831,0.00001223189,0.00006210256,0.00002823696,0.0001544158,0.996252,0.0001841748,0.0003056373,0.00212799],"study_design_scores_gemma":[0.00004242712,0.000721403,0.001053995,0.000004560771,0.00001157213,0.0001356013,0.00002833699,0.0009241187,0.9945386,0.00002183657,0.002515163,0.000002328186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826357,0.002305706,0.00734868,0.000264905,0.000260922,0.0001210059,0.001233289,0.0001478167,0.00568193],"genre_scores_gemma":[0.9875159,0.001104725,0.004480445,0.00009865687,0.00003828607,0.000076431,0.001692819,0.00001673414,0.004975994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001989843,"threshold_uncertainty_score":0.006656706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1822210576119283,"score_gpt":0.4347240222525235,"score_spread":0.2525029646405952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}