{"id":"W3020771563","doi":"10.1056/nejmoa1911440","title":"Olaparib for Metastatic Castration-Resistant Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2237,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Centre Hospitalier de l’Université de Montréal","funders":"Daiichi Sankyo Europe; Janssen Pharmaceuticals; Janssen Biotech; Foundation Medicine; Pharmacyclics; Genentech; Astellas Pharma Europe; Tulane University; Eisai; Astellas Pharma; Merck Sharp and Dohme; Radboud Universitair Medisch Centrum; EMD Serono; Radboud Universiteit; AstraZeneca; Invitae; Massachusetts Medical Society; Bayer HealthCare; Sanofi; Exelixis; Pfizer; Northwestern University; Ipsen; Clovis Oncology; F. Hoffmann-La Roche; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Olaparib; Poly ADP ribose polymerase; Prostate cancer; Homologous recombination; PARP inhibitor; DNA repair; Cancer research; Polymerase; DNA Damage Repair; Medicine; Prostate; Gene; Oncology; Cancer; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003579345,0.0002648457,0.0004389118,0.000243804,0.0001947507,0.0002411396,0.0002239455,0.0001116335,0.001016422],"category_scores_gemma":[0.0005269985,0.00006090532,0.0002442785,0.0002810013,0.0001367707,0.00008425452,0.000180697,0.0003537083,0.0001712943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512664,"about_ca_system_score_gemma":0.0006021896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006041261,"about_ca_topic_score_gemma":0.001999941,"domain_scores_codex":[0.9998605,0.00005729364,0.00000966607,0.00002030174,0.0000326911,0.00001957158],"domain_scores_gemma":[0.9997675,0.00004593225,0.00006179686,0.0000158283,0.00001721991,0.0000917774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1209391,0.002773989,0.1707389,0.002536377,0.001394423,0.004469587,0.0003255089,0.004417452,0.05956858,0.0005616625,0.01519946,0.6170749],"study_design_scores_gemma":[0.04152832,0.09500907,0.7501107,0.000651712,0.001357711,0.027186,0.0002944129,0.005534583,0.01778555,0.002139173,0.05831136,0.0000915139],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809153,0.01496996,0.0005513595,0.0003438299,0.00008341718,0.0002723265,0.0006647415,0.00004489535,0.002154189],"genre_scores_gemma":[0.9958366,0.002410103,0.0004178103,0.0002265552,0.00008022469,0.00008262217,0.0006281249,0.0000039492,0.0003139244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016422,"threshold_uncertainty_score":0.003400207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08227651790290585,"score_gpt":0.3739222685155358,"score_spread":0.2916457506126299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}