{"id":"W3020802882","doi":"10.1016/j.jhep.2020.04.030","title":"Standardisation of diet and exercise in clinical trials of NAFLD-NASH: Recommendations from the Liver Forum","year":2020,"lang":"en","type":"review","venue":"Journal of Hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Target Real-world evidence; Abbott Molecular; Genentech; Ferring Pharmaceuticals; Madrigal Pharmaceuticals; NGM Biopharmaceuticals; Intercept Pharmaceuticals; Cirius Therapeutics; Zafgen; Chimerix; National Institutes of Health; Mylan; Quest Diagnostics; Arrowhead Pharmaceuticals; Ironwood Pharmaceuticals, Incorporated; Assembly Biosciences; Takeda Pharmaceuticals U.S.A.; AiCuris; Nordic Bioscience; AbbVie; Janssen Biotech; EA Pharma Co., Ltd.; Teva Pharmaceutical Industries; Novartis; Celgene; Galectin Therapeutics; Pfizer; Biogen; Gilead Sciences; Mallinckrodt Pharmaceuticals; Inventiva Pharma; Echosens; ViiV Healthcare; Astellas Pharma US; Shire; Syneos Health; Allergan; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Roivant Sciences; Boehringer Ingelheim; GlaxoSmithKline; Durect Corporation; HepQuant","keywords":"Clinical trial; Medicine; Fatty liver; Context (archaeology); Steatohepatitis; Disease; Alternative medicine; Psychological intervention; MEDLINE; Intensive care medicine; Physical therapy; Internal medicine; Pathology; Nursing; Political science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001766843,0.0001574461,0.003830025,0.0001206072,0.0000178416,0.000004750636,0.0001019697,0.0002061038,0.0001445942],"category_scores_gemma":[0.001609436,0.00008409774,0.0009242676,0.0001111006,0.0001009753,0.00004177464,0.00005384642,0.0003340091,0.000001886893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000668905,"about_ca_system_score_gemma":0.0006090078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006900316,"about_ca_topic_score_gemma":0.00003132799,"domain_scores_codex":[0.9954375,0.0013027,0.002841167,0.0001434072,0.0001811924,0.0000940563],"domain_scores_gemma":[0.9927866,0.004048476,0.002729199,0.0001717911,0.000155311,0.0001085614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000703761,0.00049955,0.05236756,0.001450822,0.001225581,0.000111619,0.0001571839,4.608256e-8,9.738746e-8,0.00005255542,0.007163631,0.9362676],"study_design_scores_gemma":[0.004651753,0.001873754,0.01074262,0.0259069,0.01659656,0.0001021578,0.0002929892,0.0000105079,0.000006081608,0.0003104544,0.9393784,0.0001278428],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003019557,0.9926218,0.00001252841,0.002905879,0.0003066597,0.0006409154,0.0004730898,0.00000145097,0.00001806448],"genre_scores_gemma":[0.006223176,0.9931701,0.0002905174,0.00008317873,0.0001201692,0.00001521012,0.0000838161,0.00001205879,0.000001801549],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9361398,"threshold_uncertainty_score":0.3429407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2197601053258584,"score_gpt":0.4783652651535013,"score_spread":0.2586051598276429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}