{"id":"W3020804761","doi":"10.3390/pr8050503","title":"Synthesis and Characterization of New Fluoro/Trifluoromethyl-Substituted Acylthiourea Derivatives with Promising Activity against Planktonic and Biofilm-Embedded Microbial Cells","year":2020,"lang":"en","type":"article","venue":"Processes","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Ministry of Research and Innovation","keywords":"DNA gyrase; Enterococcus faecalis; Chemistry; Docking (animal); Antibacterial activity; Biofilm; Staphylococcus aureus; DPPH; Antimicrobial; Candida albicans; Minimum inhibitory concentration; Escherichia coli; Microbiology; Biochemistry; Bacteria; Antioxidant; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197925,0.0003939271,0.0002135694,0.0001870784,0.0001148686,0.0001116534,0.0002185417,0.0002613777,0.0008858277],"category_scores_gemma":[0.0001490068,0.00008667949,0.0001926271,0.0001881555,0.0001019037,0.0001838259,0.0001151227,0.0002137102,0.0003059839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515461,"about_ca_system_score_gemma":0.0001940562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007523527,"about_ca_topic_score_gemma":0.001148405,"domain_scores_codex":[0.9999381,0.00001026104,0.000006796089,0.00001152379,0.00001719367,0.00001607396],"domain_scores_gemma":[0.9999287,0.000007188899,0.00002373929,0.000005685228,0.00001911924,0.00001567283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000069286,0.00003378862,0.00006676005,0.0001002692,0.000005979269,0.00008637193,0.00001533564,0.0001896901,0.9959513,0.00005222122,0.00003697865,0.003391969],"study_design_scores_gemma":[0.00003918977,0.00112951,0.001501644,0.00001240942,0.0000305893,0.000287128,0.00001631765,0.0004323113,0.9917109,0.00002442795,0.004802373,0.00001321719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97851,0.006797628,0.01030175,0.0001365495,0.00004095001,0.0001845039,0.0006398634,0.0001184452,0.003270188],"genre_scores_gemma":[0.9808034,0.00359489,0.01173098,0.00006184716,0.00001764443,0.0001027131,0.0006462202,0.00002101993,0.003021189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008858277,"threshold_uncertainty_score":0.002963364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411359601622682,"score_gpt":0.2188098898099361,"score_spread":0.1946962937937093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}