{"id":"W3020804761","doi":"10.3390/pr8050503","title":"Synthesis and Characterization of New Fluoro/Trifluoromethyl-Substituted Acylthiourea Derivatives with Promising Activity against Planktonic and Biofilm-Embedded Microbial Cells","year":2020,"lang":"en","type":"article","venue":"Processes","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Ministry of Research and Innovation","keywords":"DNA gyrase; Enterococcus faecalis; Chemistry; Docking (animal); Antibacterial activity; Biofilm; Staphylococcus aureus; DPPH; Antimicrobial; Candida albicans; Minimum inhibitory concentration; Escherichia coli; Microbiology; Biochemistry; Bacteria; Antioxidant; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006769176,0.0002284107,0.0003996257,0.00003079018,0.00009577653,0.00006848652,0.0001151946,0.0001452848,0.00007511491],"category_scores_gemma":[0.0005626266,0.0001627416,0.0000248962,0.0002391649,0.000158203,0.0002715599,0.00006707998,0.0001325224,0.000001014363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001116145,"about_ca_system_score_gemma":0.0001402813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001758889,"about_ca_topic_score_gemma":0.000004795364,"domain_scores_codex":[0.9990574,0.00003012724,0.0001842125,0.0004118031,0.0001227727,0.0001936628],"domain_scores_gemma":[0.9990717,0.0003574585,0.000254618,0.00009908898,0.00007739729,0.0001397932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000394265,0.00009260949,0.002298579,0.001593132,0.00006084425,0.000002984102,0.0005218111,5.039406e-7,0.9642193,0.000001408295,0.00000540054,0.03080915],"study_design_scores_gemma":[0.0003155688,0.00005162249,0.003400002,0.0002076411,0.00005128495,0.000005253237,0.00009111944,0.0000548507,0.9952819,0.00000614335,0.000313789,0.0002207695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985638,0.000244191,0.0002381084,0.0004559856,0.00001037543,0.0001230198,0.0001090305,0.00007739155,0.0001780684],"genre_scores_gemma":[0.9980156,0.0006131433,0.00117554,0.00004673282,0.00008541361,0.00001245735,0.00002104548,0.00001647268,0.00001360624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03106264,"threshold_uncertainty_score":0.6636408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411359601622682,"score_gpt":0.2188098898099361,"score_spread":0.1946962937937093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}