{"id":"W3020841146","doi":"10.1021/acsomega.0c00207","title":"Promising Performance of 4HMS, a New Zirconium-89 Octadendate Chelator","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Université de Sherbrooke","keywords":"Chelation; Biodistribution; Chemistry; In vivo; Transmetalation; Zirconium; Radiochemistry; Positron emission tomography; Bifunctional; Clearance; Nuclear chemistry; Combinatorial chemistry; In vitro; Nuclear medicine; Inorganic chemistry; Organic chemistry; Biochemistry; Catalysis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004219033,0.00008651285,0.0001788637,0.0000118221,0.00003539414,0.000007301946,0.00009732366,0.0000560138,0.0000778552],"category_scores_gemma":[0.000060541,0.00007797227,0.00004318137,0.0002132377,0.0000518612,0.00006857122,0.00002849238,0.0001933154,0.00007871116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001593426,"about_ca_system_score_gemma":0.0001073982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002320419,"about_ca_topic_score_gemma":2.990685e-8,"domain_scores_codex":[0.9993569,0.000004328935,0.0001919079,0.0001694272,0.0001314253,0.0001460638],"domain_scores_gemma":[0.9994459,0.00002129841,0.00005372926,0.0001674187,0.00003395568,0.0002777489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001317932,0.00004705071,0.002218539,0.0003030316,0.00003773769,0.000004745556,0.0002311134,0.000005994843,0.9903657,0.0001463004,0.00303057,0.003477372],"study_design_scores_gemma":[0.0009363904,0.00008202948,0.002251965,0.0000529498,0.00007300267,0.00002317086,0.00002380238,0.0008673324,0.9340157,0.00001616476,0.06157303,0.0000844727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98599,0.0002713428,0.00007010804,0.009044611,0.00001499155,0.0001811863,0.000005966395,0.0000548009,0.004366931],"genre_scores_gemma":[0.9966299,0.00006927998,0.0008682244,0.00108255,0.0002949047,0.000008088401,0.00001374017,0.00001225471,0.001021062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05854246,"threshold_uncertainty_score":0.3179617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05150747890076066,"score_gpt":0.3079633295413438,"score_spread":0.2564558506405831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}