{"id":"W3020862607","doi":"10.1126/sciadv.aaz4848","title":"Attenuated diphtheria toxin mediates siRNA delivery","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Diphtheria toxin; Diphtheria; Toxin; Small interfering RNA; Virology; Immunization; Corynebacterium diphtheriae; Biology; Microbiology; Medicine; Immunology; Vaccination; Transfection; Genetics; Cell culture; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001907484,0.000423803,0.0003355911,0.000185435,0.0001415697,0.0003812359,0.0002262755,0.0005302448,0.001787148],"category_scores_gemma":[0.000145028,0.0001678916,0.000248232,0.0001402117,0.0002660463,0.0001656937,0.0002573674,0.0009973324,0.001031224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005088635,"about_ca_system_score_gemma":0.000424805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009669897,"about_ca_topic_score_gemma":0.001514441,"domain_scores_codex":[0.9997415,0.0000293037,0.00002737199,0.0000618911,0.00008371957,0.00005621213],"domain_scores_gemma":[0.9998507,0.00004399508,0.0000334025,0.00002375723,0.00002406236,0.00002398481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003376038,0.000008301094,0.00002402812,0.00002290249,0.000003330384,0.00003585913,0.00001154296,0.00003322255,0.9988917,0.0002085165,0.00007110978,0.0006557085],"study_design_scores_gemma":[0.000006366547,0.00007490435,0.0002536133,0.000002520946,0.000006208038,0.00007808618,0.000005390536,0.0003155462,0.9969543,0.00002846771,0.002273089,0.000001396055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449477,0.003402682,0.03317239,0.0005191892,0.0003348103,0.000211409,0.002041879,0.0006117275,0.01475823],"genre_scores_gemma":[0.9731629,0.001506921,0.007098857,0.000179635,0.00001221781,0.0001130488,0.001620947,0.00009980513,0.01620572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001787148,"threshold_uncertainty_score":0.005978644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427453863642187,"score_gpt":0.2623791997787157,"score_spread":0.2481046611422938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}