{"id":"W3020862607","doi":"10.1126/sciadv.aaz4848","title":"Attenuated diphtheria toxin mediates siRNA delivery","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Diphtheria toxin; Diphtheria; Toxin; Small interfering RNA; Virology; Immunization; Corynebacterium diphtheriae; Biology; Microbiology; Medicine; Immunology; Vaccination; Transfection; Genetics; Cell culture; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282333,0.0001147771,0.00009811586,0.00002851197,0.0001297609,0.00004633265,0.000512242,0.0000404207,0.00005338259],"category_scores_gemma":[0.0001684036,0.00009643712,0.00004437395,0.0002979763,0.0003928038,0.0000352039,0.000145275,0.00005400525,0.0001080615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007467705,"about_ca_system_score_gemma":0.0001148181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006453003,"about_ca_topic_score_gemma":0.00001214742,"domain_scores_codex":[0.9989262,0.00001663308,0.0001363989,0.0004341216,0.0002095245,0.0002771232],"domain_scores_gemma":[0.9994816,0.000007764251,0.00005667734,0.0001847982,0.0001213453,0.000147815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003660933,0.000009921963,0.001775731,0.000004253255,0.00000499022,0.000002824141,0.00008438418,0.0001115167,0.9869347,0.000008765114,0.0005607025,0.01046567],"study_design_scores_gemma":[0.0001588975,0.0003394475,0.001234864,0.000007780892,0.000004380495,0.000003319696,0.0003089432,0.0001302538,0.970989,0.00006720339,0.02658552,0.0001704205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951442,0.002266344,0.00027258,0.0007165982,0.0002326624,0.00007279597,0.00001103482,0.00002166915,0.001262089],"genre_scores_gemma":[0.9970608,0.0003666879,0.0005001835,0.001648194,0.0002319536,0.000007172292,0.00001428925,0.000007611447,0.0001631295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02602482,"threshold_uncertainty_score":0.3932591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427453863642187,"score_gpt":0.2623791997787157,"score_spread":0.2481046611422938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}