{"id":"W3020928354","doi":"10.1016/j.phrs.2020.104853","title":"Possible use of the mucolytic drug, bromhexine hydrochloride, as a prophylactic agent against SARS-CoV-2 infection based on its action on the Transmembrane Serine Protease 2","year":2020,"lang":"en","type":"letter","venue":"Pharmacological Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Medicine; Drug; Serine protease; Pharmacology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Hydrochloride; Protease; Coronavirus disease 2019 (COVID-19); Virology; Chemistry; Enzyme; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002071238,0.000707147,0.0008874021,0.0007410589,0.0006391791,0.0002419686,0.0009533838,0.0008219939,0.0002464992],"category_scores_gemma":[0.004945148,0.0003776097,0.0006778878,0.002746113,0.000720817,0.000178069,0.0003228601,0.01394462,0.0006802478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001139707,"about_ca_system_score_gemma":0.001873551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004063857,"about_ca_topic_score_gemma":0.00001392814,"domain_scores_codex":[0.988783,0.002972802,0.0007809049,0.001306996,0.004763989,0.001392319],"domain_scores_gemma":[0.9940906,0.003547766,0.000281097,0.0009844929,0.0009455388,0.000150524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01045118,0.001559596,0.0001499746,0.00256566,0.0002756325,0.002012933,0.00007795486,0.00004836714,0.8072457,0.00001222638,0.1736526,0.001948114],"study_design_scores_gemma":[0.002173624,0.002663811,0.0002469687,0.0004090775,0.0001654603,0.00001916402,0.000006615867,0.008671755,0.6592129,0.00006315651,0.3261003,0.0002671744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6124813,0.00004298687,0.000007275613,0.3770527,0.0003060839,0.008128354,0.00004285797,0.0001252966,0.001813167],"genre_scores_gemma":[0.5089192,0.00004192724,0.00000463994,0.4876231,0.001210116,0.001574056,0.00002321428,0.00008132056,0.0005223994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1524476,"threshold_uncertainty_score":0.9998676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3083781506282511,"score_gpt":0.4529742212005203,"score_spread":0.1445960705722693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}