{"id":"W3020986724","doi":"10.1038/s41419-020-2500-6","title":"Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Concordia University; Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Children's Health Research Institute","keywords":"Cytotrophoblast; Syncytiotrophoblast; Biology; Cell biology; Trophoblast; Histone; Cellular differentiation; Syncytium; Chromatin remodeling; Cell fusion; Histone deacetylase 2; Epigenetics; Histone deacetylase; Genetics; Placenta; Cell; Gene; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415288,0.0001482033,0.0001574996,0.0001733252,0.0001212634,0.0002328191,0.00009823261,0.000133003,0.001279475],"category_scores_gemma":[0.0001355447,0.0001577049,0.0002307922,0.0001454121,0.0001556344,0.00009533534,0.0002624805,0.0002392211,0.0002864381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002277202,"about_ca_system_score_gemma":0.0001743775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186344,"about_ca_topic_score_gemma":0.001617297,"domain_scores_codex":[0.9999206,0.000009459678,0.000008643522,0.00002692507,0.00001660798,0.00001768148],"domain_scores_gemma":[0.9999511,0.00001130189,0.00001186273,0.000007696474,0.000003995274,0.00001390297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001193636,0.00001178356,0.000569935,0.00001754806,0.000004700045,0.00003849341,0.00002636689,0.00004872208,0.9979748,0.00008303664,0.0000314463,0.001073785],"study_design_scores_gemma":[0.00003065018,0.0002665461,0.02034353,0.000003956483,0.00001931463,0.0002652422,0.00006985173,0.001516509,0.9737843,0.00009633281,0.00359943,0.0000044474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945284,0.001453142,0.002240197,0.00006405878,0.00001922273,0.00002898344,0.0004078016,0.0000549381,0.001203375],"genre_scores_gemma":[0.9957581,0.0005344817,0.001117324,0.00003863855,0.000004791143,0.00002397432,0.0005949209,0.00001223759,0.001915491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279475,"threshold_uncertainty_score":0.004280269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007265753595558234,"score_gpt":0.2294193969847481,"score_spread":0.2221536433891898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}