{"id":"W3020986724","doi":"10.1038/s41419-020-2500-6","title":"Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Concordia University; Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Children's Health Research Institute","keywords":"Cytotrophoblast; Syncytiotrophoblast; Biology; Cell biology; Trophoblast; Histone; Cellular differentiation; Syncytium; Chromatin remodeling; Cell fusion; Histone deacetylase 2; Epigenetics; Histone deacetylase; Genetics; Placenta; Cell; Gene; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002514265,0.00008509619,0.00008551145,0.00002175399,0.00003799286,0.00001040514,0.0000223635,0.00004739091,0.000004122177],"category_scores_gemma":[0.00001723956,0.00008302205,0.00001928373,0.00002339627,0.00003823524,0.0000031623,0.00005740854,0.00002925696,2.525676e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004109461,"about_ca_system_score_gemma":0.00001946163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009182348,"about_ca_topic_score_gemma":0.000005109954,"domain_scores_codex":[0.9995055,0.00002792362,0.0001157699,0.0002138371,0.00005400223,0.00008295661],"domain_scores_gemma":[0.9996129,0.000004794563,0.00004751913,0.00006256929,0.00001661125,0.0002556072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000162925,0.00006388162,0.05233026,0.00009253126,0.000003002475,0.000002805602,0.00009997476,0.000007588369,0.9465915,0.000009900594,0.00001902055,0.0006166274],"study_design_scores_gemma":[0.001371906,0.0002837279,0.1409191,0.00001109586,0.00003348205,2.120156e-7,0.00004817824,0.0007350771,0.8562087,0.00008306991,0.0001800171,0.0001254618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957345,0.00380595,0.0001629952,0.00003243721,0.00001862971,0.0001635146,0.00003207757,0.000002721613,0.00004719079],"genre_scores_gemma":[0.9989741,0.0006896091,0.0001147406,0.0000369451,0.0000432528,0.000005582704,0.00009608821,0.000007764232,0.00003192558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0903828,"threshold_uncertainty_score":0.3385541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007265753595558234,"score_gpt":0.2294193969847481,"score_spread":0.2221536433891898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}