{"id":"W3020988432","doi":"10.1021/acsmedchemlett.9b00599","title":"Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors","year":2020,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hunter Family Foundation; National Cancer Institute; Uncle Kory Foundation; Ziering Family Foundation; National Brain Tumor Society","keywords":"Penetrant (biochemical); Tyrosine-kinase inhibitor; Protein-Tyrosine Kinases; Cancer research; Tyrosine kinase; Medicine; Pharmacology; Chemistry; Internal medicine; Receptor; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307371,0.0002778859,0.0004460466,0.00003926777,0.00008564337,0.0000103351,0.0001373204,0.00006839645,0.00008408422],"category_scores_gemma":[0.0001421285,0.0002244954,0.0001043549,0.0002468677,0.0001410262,0.00004758848,0.00004997501,0.0002236956,0.00001464355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647581,"about_ca_system_score_gemma":0.0004477884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002177567,"about_ca_topic_score_gemma":0.000001656276,"domain_scores_codex":[0.998078,0.00001534388,0.0005622599,0.0004136565,0.0005801405,0.0003506289],"domain_scores_gemma":[0.9989917,0.00006188246,0.0001793268,0.000242702,0.00008242638,0.0004419743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002034155,0.0001551722,0.0006818639,0.0006872324,0.0002217752,0.0007542588,0.002891111,0.00001542203,0.9741538,0.000004129084,0.01417412,0.006057685],"study_design_scores_gemma":[0.004251237,0.0001359408,0.00261529,0.0009287746,0.000231391,0.00009729349,0.00123339,0.00004070413,0.9733755,0.000001708501,0.01682014,0.0002686281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.893818,0.0003262269,0.000324971,0.1041838,0.00007692363,0.0003208893,0.00002278114,0.00005720532,0.0008691736],"genre_scores_gemma":[0.9659554,0.00001134137,0.002326231,0.03078264,0.0004184154,0.0000409344,0.0002706637,0.00003644918,0.000157881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07340117,"threshold_uncertainty_score":0.9154655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01519337616604374,"score_gpt":0.2690824842700128,"score_spread":0.2538891081039691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}