{"id":"W3021032174","doi":"10.1016/j.cell.2020.04.009","title":"Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":246,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Technische Universität Dresden; Boehringer Ingelheim Fonds; Max-Planck-Gesellschaft; Volkswagen Foundation; European Research Council; Human Frontier Science Program","keywords":"Biology; Translation (biology); Protein biosynthesis; Housekeeping gene; Ribosome profiling; Cell biology; Heat shock protein; Heat shock; Messenger RNA; Gene; Gene expression; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005511844,0.00005473253,0.00006508283,0.00001567108,0.00002692161,0.000008937871,0.00007049378,0.0000440757,0.00001513732],"category_scores_gemma":[0.00007758023,0.00005527792,0.00002748412,0.00006381932,0.00001448027,0.00000328942,0.00002051723,0.00004535665,0.000007222917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003329296,"about_ca_system_score_gemma":0.00004645401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000032173,"about_ca_topic_score_gemma":0.00002020941,"domain_scores_codex":[0.9994448,0.00002659814,0.0001100846,0.0002035153,0.0001174673,0.00009756266],"domain_scores_gemma":[0.9997274,0.000003138363,0.00003474439,0.00009618504,0.00006914214,0.00006941524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008238097,0.00002496261,0.0007604779,0.00004104283,0.000009230369,4.70466e-7,0.000209793,0.000225118,0.9976918,0.000004137146,0.00009916772,0.0008514982],"study_design_scores_gemma":[0.0001908451,0.0001539555,0.001111656,0.00001790635,0.000003408478,1.807996e-7,0.0000505274,0.0003306615,0.9976979,0.00003496359,0.0003473784,0.00006054321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936213,0.0001058269,0.004655361,0.001077803,0.00001731828,0.0003680095,0.00002154525,0.000007789689,0.0001250577],"genre_scores_gemma":[0.9976579,0.00000363751,0.001770743,0.00006434662,0.0001810433,0.00001888925,0.00009408912,0.000009702012,0.0001996249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004036635,"threshold_uncertainty_score":0.2254168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969345718576838,"score_gpt":0.2488678165740912,"score_spread":0.2291743593883228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}