{"id":"W3021148913","doi":"10.1002/path.5455","title":"Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis","year":2020,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; “la Caixa” Foundation; Agence Nationale de la Recherche; Academy of Medical Sciences; Pathological Society of Great Britain and Ireland; National Institute for Health and Care Research","keywords":"Oligodendrocyte; Amyotrophic lateral sclerosis; C9orf72; Biology; Myelin basic protein; Myelin; Pathology; Glial fibrillary acidic protein; White matter; Spinal cord; Immunohistochemistry; Central nervous system; Neuroscience; Immunology; Medicine; Frontotemporal dementia; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001615195,0.0003563596,0.0002412164,0.001459999,0.0003487557,0.0003847087,0.0001063405,0.000292361,0.001315053],"category_scores_gemma":[0.0001625266,0.0002025278,0.0001282226,0.0004520665,0.000344335,0.0002064622,0.0002836375,0.0001715014,0.0002697187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001834316,"about_ca_system_score_gemma":0.000181239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00186774,"about_ca_topic_score_gemma":0.002389378,"domain_scores_codex":[0.999895,0.000009483815,0.00001438289,0.00002812543,0.0000411061,0.00001180345],"domain_scores_gemma":[0.9998733,0.00001010026,0.00004593904,0.000007811308,0.00002505513,0.00003784573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000940933,0.00009343815,0.0412328,0.0002711611,0.0001097884,0.003796373,0.0003531664,0.00008517163,0.9452445,0.0002041718,0.0002967698,0.007371831],"study_design_scores_gemma":[0.00001885713,0.0004096752,0.9426069,0.00003603544,0.0001135179,0.008587984,0.0001914694,0.0002904674,0.04525478,0.0004180708,0.002058946,0.0000133814],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945948,0.002807372,0.0003771164,0.00003556612,0.00001427707,0.00001575987,0.0002501581,0.0000566315,0.001848428],"genre_scores_gemma":[0.9967635,0.001406434,0.0004697973,0.00003960867,0.0000193488,0.00001260239,0.0002934429,0.00001468921,0.0009805984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186774,"threshold_uncertainty_score":0.0043993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0512817396991768,"score_gpt":0.2987711405994999,"score_spread":0.2474894009003231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}