{"id":"W3021208601","doi":"10.1101/2020.04.29.068585","title":"UV damage induces G3BP1-dependent stress granule formation that is not driven by translation arrest via mTOR inhibition","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Dalhousie University","keywords":"Stress granule; Cell biology; EIF4E; Translation (biology); Chemistry; Initiation factor; Transcription preinitiation complex; Poly(A)-binding protein; Biology; Messenger RNA; Biochemistry; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007987011,0.0002901459,0.0002697413,0.0002577733,0.0001720778,0.0002314431,0.000149504,0.0002649447,0.002234575],"category_scores_gemma":[0.00008583278,0.0001427114,0.0002446696,0.0001473254,0.0002001046,0.0001129193,0.0001917419,0.0004346011,0.000930473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046235,"about_ca_system_score_gemma":0.000132783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005597074,"about_ca_topic_score_gemma":0.0005341229,"domain_scores_codex":[0.9999098,0.00001261015,0.000008243081,0.00002479192,0.00002230206,0.00002228582],"domain_scores_gemma":[0.9999242,0.00001371143,0.00002162423,0.00001635769,0.00000691847,0.00001720032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00011128,0.00001308744,0.00009026137,0.00002855169,0.0000033807,0.00003902078,0.000005988888,0.00003044932,0.9990368,0.00007186237,0.00008822388,0.0004812109],"study_design_scores_gemma":[0.000009126252,0.00006434027,0.006541497,0.000004768733,0.000004341244,0.0001216583,0.000008536387,0.0004954019,0.9908521,0.00005675622,0.001838765,0.000002786734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989791,0.002246798,0.002412642,0.0001434428,0.00008098894,0.00003706049,0.00131292,0.0002800098,0.00369516],"genre_scores_gemma":[0.9902425,0.0006496531,0.001447895,0.00007109263,0.00001846515,0.00004120385,0.001765189,0.00008294025,0.005681085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234575,"threshold_uncertainty_score":0.007475436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192148168577986,"score_gpt":0.2411792562242381,"score_spread":0.2192577745384582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}