{"id":"W3021208723","doi":"10.1007/s12022-020-09624-3","title":"Immunohistochemical Analysis of the Metabolic Phenotype of Adrenal Cortical Carcinoma","year":2020,"lang":"en","type":"article","venue":"Endocrine Pathology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"PKM2; Pyruvate kinase; Tissue microarray; Immunohistochemistry; Glycolysis; SDHB; Carcinogenesis; Endocrinology; Internal medicine; Phenotype; Biology; Isozyme; Cancer research; Cancer; Medicine; Metabolism; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007093165,0.0001293132,0.0004523944,0.00005092511,0.00002862962,0.000001907922,0.000299607,0.00007254657,0.00009959614],"category_scores_gemma":[0.0002642728,0.0001001027,0.000361402,0.0003872088,0.0002710148,0.000001599915,0.0002289417,0.0001411177,0.000002322618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003603897,"about_ca_system_score_gemma":0.00008154714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003377089,"about_ca_topic_score_gemma":0.00001259729,"domain_scores_codex":[0.9989125,0.0001252029,0.0003409263,0.0002844633,0.0001257954,0.0002110959],"domain_scores_gemma":[0.9992422,0.0000186191,0.000147587,0.0004201799,0.00009853503,0.00007289302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001497335,0.00004901075,0.008490024,0.00001041156,0.0003081333,0.000002694197,0.0001172298,0.00005055069,0.9887326,0.0006308764,0.0005719476,0.0008867681],"study_design_scores_gemma":[0.0008081373,0.0001623781,0.1768242,0.000001817194,0.001320443,0.00003320393,0.00004651788,0.0001317456,0.7765303,0.00002179049,0.04397194,0.0001475032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902381,0.008059206,0.0004701379,0.0002748471,0.0003408693,0.00009861272,0.00007923118,0.000005365622,0.0004335777],"genre_scores_gemma":[0.9984657,0.0002494354,0.000327181,0.0003767619,0.0004168017,0.00001058986,0.00006109894,0.00001254373,0.00007994138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2122023,"threshold_uncertainty_score":0.4082069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082477038011648,"score_gpt":0.249040279616455,"score_spread":0.2382155092363386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}